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Molecular Events Occurring in Lipophagy and Its Regulation in Flaviviridae Infection

Diseases caused by Flaviviridae have a wide global and economic impact due to high morbidity and mortality. Flaviviridae infection usually leads to severe, acute or chronic diseases, such as liver injury and liver cancer resulting from hepatitis C virus (HCV) infection, dengue hemorrhagic fever (DHF...

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Autores principales: Wu, Keke, Fan, Shuangqi, Zou, Linke, Zhao, Feifan, Ma, Shengming, Fan, Jindai, Li, Xiaowen, Zhao, Mingqiu, Yan, Huichao, Chen, Jinding
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8175637/
https://www.ncbi.nlm.nih.gov/pubmed/34093468
http://dx.doi.org/10.3389/fmicb.2021.651952
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author Wu, Keke
Fan, Shuangqi
Zou, Linke
Zhao, Feifan
Ma, Shengming
Fan, Jindai
Li, Xiaowen
Zhao, Mingqiu
Yan, Huichao
Chen, Jinding
author_facet Wu, Keke
Fan, Shuangqi
Zou, Linke
Zhao, Feifan
Ma, Shengming
Fan, Jindai
Li, Xiaowen
Zhao, Mingqiu
Yan, Huichao
Chen, Jinding
author_sort Wu, Keke
collection PubMed
description Diseases caused by Flaviviridae have a wide global and economic impact due to high morbidity and mortality. Flaviviridae infection usually leads to severe, acute or chronic diseases, such as liver injury and liver cancer resulting from hepatitis C virus (HCV) infection, dengue hemorrhagic fever (DHF) or dengue shock syndrome (DSS) caused by dengue virus (DENV). Given the highly complex pathogenesis of Flaviviridae infections, they are still not fully understood at present. Accumulating evidence suggests that host autophagy is disrupted to regulate the life cycle of Flaviviridae. Organelle-specific autophagy is able to selectively target different organelles for quality control, which is essential for regulating cellular homeostasis. As an important sub process of autophagy, lipophagy regulates lipid metabolism by targeting lipid droplets (LDs) and is also closely related to the infection of a variety of pathogenic microorganisms. In this review, we briefly understand the LDs interaction relationship with Flaviviridae infection, outline the molecular events of how lipophagy occurs and the related research progress on the regulatory mechanisms of lipophagy in Flaviviridae infection. Exploring the crosstalk between viral infection and lipophagy induced molecular events may provide new avenues for antiviral therapy.
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spelling pubmed-81756372021-06-05 Molecular Events Occurring in Lipophagy and Its Regulation in Flaviviridae Infection Wu, Keke Fan, Shuangqi Zou, Linke Zhao, Feifan Ma, Shengming Fan, Jindai Li, Xiaowen Zhao, Mingqiu Yan, Huichao Chen, Jinding Front Microbiol Microbiology Diseases caused by Flaviviridae have a wide global and economic impact due to high morbidity and mortality. Flaviviridae infection usually leads to severe, acute or chronic diseases, such as liver injury and liver cancer resulting from hepatitis C virus (HCV) infection, dengue hemorrhagic fever (DHF) or dengue shock syndrome (DSS) caused by dengue virus (DENV). Given the highly complex pathogenesis of Flaviviridae infections, they are still not fully understood at present. Accumulating evidence suggests that host autophagy is disrupted to regulate the life cycle of Flaviviridae. Organelle-specific autophagy is able to selectively target different organelles for quality control, which is essential for regulating cellular homeostasis. As an important sub process of autophagy, lipophagy regulates lipid metabolism by targeting lipid droplets (LDs) and is also closely related to the infection of a variety of pathogenic microorganisms. In this review, we briefly understand the LDs interaction relationship with Flaviviridae infection, outline the molecular events of how lipophagy occurs and the related research progress on the regulatory mechanisms of lipophagy in Flaviviridae infection. Exploring the crosstalk between viral infection and lipophagy induced molecular events may provide new avenues for antiviral therapy. Frontiers Media S.A. 2021-05-21 /pmc/articles/PMC8175637/ /pubmed/34093468 http://dx.doi.org/10.3389/fmicb.2021.651952 Text en Copyright © 2021 Wu, Fan, Zou, Zhao, Ma, Fan, Li, Zhao, Yan and Chen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Wu, Keke
Fan, Shuangqi
Zou, Linke
Zhao, Feifan
Ma, Shengming
Fan, Jindai
Li, Xiaowen
Zhao, Mingqiu
Yan, Huichao
Chen, Jinding
Molecular Events Occurring in Lipophagy and Its Regulation in Flaviviridae Infection
title Molecular Events Occurring in Lipophagy and Its Regulation in Flaviviridae Infection
title_full Molecular Events Occurring in Lipophagy and Its Regulation in Flaviviridae Infection
title_fullStr Molecular Events Occurring in Lipophagy and Its Regulation in Flaviviridae Infection
title_full_unstemmed Molecular Events Occurring in Lipophagy and Its Regulation in Flaviviridae Infection
title_short Molecular Events Occurring in Lipophagy and Its Regulation in Flaviviridae Infection
title_sort molecular events occurring in lipophagy and its regulation in flaviviridae infection
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8175637/
https://www.ncbi.nlm.nih.gov/pubmed/34093468
http://dx.doi.org/10.3389/fmicb.2021.651952
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