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Comprehensive profiling of novel epithelial–mesenchymal transition mediators and their clinical significance in colorectal cancer

Epithelial–mesenchymal transition (EMT) is a drastic phenotypic change during cancer metastasis and is one of the most important hallmarks of aggressive cancer. Although the overexpression of some specific transcription factors explains the functional alteration of EMT-induced cells, a complete pict...

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Autores principales: Ishikawa, Satoshi, Nishida, Naohiro, Fujino, Shiki, Ogino, Takayuki, Takahashi, Hidekazu, Miyoshi, Norikatsu, Uemura, Mamoru, Satoh, Taroh, Yamamoto, Hirofumi, Mizushima, Tsunekazu, Doki, Yuichiro, Eguchi, Hidetoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8175715/
https://www.ncbi.nlm.nih.gov/pubmed/34083586
http://dx.doi.org/10.1038/s41598-021-91102-9
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author Ishikawa, Satoshi
Nishida, Naohiro
Fujino, Shiki
Ogino, Takayuki
Takahashi, Hidekazu
Miyoshi, Norikatsu
Uemura, Mamoru
Satoh, Taroh
Yamamoto, Hirofumi
Mizushima, Tsunekazu
Doki, Yuichiro
Eguchi, Hidetoshi
author_facet Ishikawa, Satoshi
Nishida, Naohiro
Fujino, Shiki
Ogino, Takayuki
Takahashi, Hidekazu
Miyoshi, Norikatsu
Uemura, Mamoru
Satoh, Taroh
Yamamoto, Hirofumi
Mizushima, Tsunekazu
Doki, Yuichiro
Eguchi, Hidetoshi
author_sort Ishikawa, Satoshi
collection PubMed
description Epithelial–mesenchymal transition (EMT) is a drastic phenotypic change during cancer metastasis and is one of the most important hallmarks of aggressive cancer. Although the overexpression of some specific transcription factors explains the functional alteration of EMT-induced cells, a complete picture of this biological process is yet to be elucidated. To comprehensively profile EMT-related genes in colorectal cancer, we quantified the EMT induction ability of each gene according to its similarity to the cancer stromal gene signature and termed it “mesenchymal score.” This bioinformatic approach successfully identified 90 candidate EMT mediators, which are strongly predictive of survival in clinical samples. Among these candidates, we discovered that the neuronal gene ARC, possibly originating from the retrotransposon, unexpectedly plays a crucial role in EMT induction. Profiling of novel EMT mediators we demonstrated here may help understand the complexity of the EMT program and open up new avenues for therapeutic intervention in colorectal cancer.
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spelling pubmed-81757152021-06-07 Comprehensive profiling of novel epithelial–mesenchymal transition mediators and their clinical significance in colorectal cancer Ishikawa, Satoshi Nishida, Naohiro Fujino, Shiki Ogino, Takayuki Takahashi, Hidekazu Miyoshi, Norikatsu Uemura, Mamoru Satoh, Taroh Yamamoto, Hirofumi Mizushima, Tsunekazu Doki, Yuichiro Eguchi, Hidetoshi Sci Rep Article Epithelial–mesenchymal transition (EMT) is a drastic phenotypic change during cancer metastasis and is one of the most important hallmarks of aggressive cancer. Although the overexpression of some specific transcription factors explains the functional alteration of EMT-induced cells, a complete picture of this biological process is yet to be elucidated. To comprehensively profile EMT-related genes in colorectal cancer, we quantified the EMT induction ability of each gene according to its similarity to the cancer stromal gene signature and termed it “mesenchymal score.” This bioinformatic approach successfully identified 90 candidate EMT mediators, which are strongly predictive of survival in clinical samples. Among these candidates, we discovered that the neuronal gene ARC, possibly originating from the retrotransposon, unexpectedly plays a crucial role in EMT induction. Profiling of novel EMT mediators we demonstrated here may help understand the complexity of the EMT program and open up new avenues for therapeutic intervention in colorectal cancer. Nature Publishing Group UK 2021-06-03 /pmc/articles/PMC8175715/ /pubmed/34083586 http://dx.doi.org/10.1038/s41598-021-91102-9 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Ishikawa, Satoshi
Nishida, Naohiro
Fujino, Shiki
Ogino, Takayuki
Takahashi, Hidekazu
Miyoshi, Norikatsu
Uemura, Mamoru
Satoh, Taroh
Yamamoto, Hirofumi
Mizushima, Tsunekazu
Doki, Yuichiro
Eguchi, Hidetoshi
Comprehensive profiling of novel epithelial–mesenchymal transition mediators and their clinical significance in colorectal cancer
title Comprehensive profiling of novel epithelial–mesenchymal transition mediators and their clinical significance in colorectal cancer
title_full Comprehensive profiling of novel epithelial–mesenchymal transition mediators and their clinical significance in colorectal cancer
title_fullStr Comprehensive profiling of novel epithelial–mesenchymal transition mediators and their clinical significance in colorectal cancer
title_full_unstemmed Comprehensive profiling of novel epithelial–mesenchymal transition mediators and their clinical significance in colorectal cancer
title_short Comprehensive profiling of novel epithelial–mesenchymal transition mediators and their clinical significance in colorectal cancer
title_sort comprehensive profiling of novel epithelial–mesenchymal transition mediators and their clinical significance in colorectal cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8175715/
https://www.ncbi.nlm.nih.gov/pubmed/34083586
http://dx.doi.org/10.1038/s41598-021-91102-9
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