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Concurrent electrophysiological recording and cognitive testing in a rodent touchscreen environment

Challenges in therapeutics development for neuropsychiatric disorders can be attributed, in part, to a paucity of translational models capable of capturing relevant phenotypes across clinical populations and laboratory animals. Touch-sensitive procedures are increasingly used to develop innovative a...

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Autores principales: Kangas, Brian D., Iturra-Mena, Ann M., Robble, Mykel A., Luc, Oanh T., Potter, David, Nickels, Stefanie, Bergman, Jack, Carlezon, William A., Pizzagalli, Diego A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8175731/
https://www.ncbi.nlm.nih.gov/pubmed/34083596
http://dx.doi.org/10.1038/s41598-021-91091-9
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author Kangas, Brian D.
Iturra-Mena, Ann M.
Robble, Mykel A.
Luc, Oanh T.
Potter, David
Nickels, Stefanie
Bergman, Jack
Carlezon, William A.
Pizzagalli, Diego A.
author_facet Kangas, Brian D.
Iturra-Mena, Ann M.
Robble, Mykel A.
Luc, Oanh T.
Potter, David
Nickels, Stefanie
Bergman, Jack
Carlezon, William A.
Pizzagalli, Diego A.
author_sort Kangas, Brian D.
collection PubMed
description Challenges in therapeutics development for neuropsychiatric disorders can be attributed, in part, to a paucity of translational models capable of capturing relevant phenotypes across clinical populations and laboratory animals. Touch-sensitive procedures are increasingly used to develop innovative animal models that better align with testing conditions used in human participants. In addition, advances in electrophysiological techniques have identified neurophysiological signatures associated with characteristics of neuropsychiatric illness. The present studies integrated these methodologies by developing a rat flanker task with electrophysiological recordings based on reverse-translated protocols used in human electroencephalogram (EEG) studies of cognitive control. Various touchscreen-based stimuli were evaluated for their ability to efficiently gain stimulus control and advance to flanker test sessions. Optimized stimuli were then examined for their elicitation of prototypical visual evoked potentials (VEPs) across local field potential (LFP) wires and EEG skull screws. Of the stimuli evaluated, purple and green photographic stimuli were associated with efficient training and expected flanker interference effects. Orderly stimulus-locked outcomes were also observed in VEPs across LFP and EEG recordings. These studies along with others verify the feasibility of concurrent electrophysiological recordings and rodent touchscreen-based cognitive testing and encourage future use of this integrated approach in therapeutics development.
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spelling pubmed-81757312021-06-07 Concurrent electrophysiological recording and cognitive testing in a rodent touchscreen environment Kangas, Brian D. Iturra-Mena, Ann M. Robble, Mykel A. Luc, Oanh T. Potter, David Nickels, Stefanie Bergman, Jack Carlezon, William A. Pizzagalli, Diego A. Sci Rep Article Challenges in therapeutics development for neuropsychiatric disorders can be attributed, in part, to a paucity of translational models capable of capturing relevant phenotypes across clinical populations and laboratory animals. Touch-sensitive procedures are increasingly used to develop innovative animal models that better align with testing conditions used in human participants. In addition, advances in electrophysiological techniques have identified neurophysiological signatures associated with characteristics of neuropsychiatric illness. The present studies integrated these methodologies by developing a rat flanker task with electrophysiological recordings based on reverse-translated protocols used in human electroencephalogram (EEG) studies of cognitive control. Various touchscreen-based stimuli were evaluated for their ability to efficiently gain stimulus control and advance to flanker test sessions. Optimized stimuli were then examined for their elicitation of prototypical visual evoked potentials (VEPs) across local field potential (LFP) wires and EEG skull screws. Of the stimuli evaluated, purple and green photographic stimuli were associated with efficient training and expected flanker interference effects. Orderly stimulus-locked outcomes were also observed in VEPs across LFP and EEG recordings. These studies along with others verify the feasibility of concurrent electrophysiological recordings and rodent touchscreen-based cognitive testing and encourage future use of this integrated approach in therapeutics development. Nature Publishing Group UK 2021-06-03 /pmc/articles/PMC8175731/ /pubmed/34083596 http://dx.doi.org/10.1038/s41598-021-91091-9 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Kangas, Brian D.
Iturra-Mena, Ann M.
Robble, Mykel A.
Luc, Oanh T.
Potter, David
Nickels, Stefanie
Bergman, Jack
Carlezon, William A.
Pizzagalli, Diego A.
Concurrent electrophysiological recording and cognitive testing in a rodent touchscreen environment
title Concurrent electrophysiological recording and cognitive testing in a rodent touchscreen environment
title_full Concurrent electrophysiological recording and cognitive testing in a rodent touchscreen environment
title_fullStr Concurrent electrophysiological recording and cognitive testing in a rodent touchscreen environment
title_full_unstemmed Concurrent electrophysiological recording and cognitive testing in a rodent touchscreen environment
title_short Concurrent electrophysiological recording and cognitive testing in a rodent touchscreen environment
title_sort concurrent electrophysiological recording and cognitive testing in a rodent touchscreen environment
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8175731/
https://www.ncbi.nlm.nih.gov/pubmed/34083596
http://dx.doi.org/10.1038/s41598-021-91091-9
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