Cargando…
Serum Folate, Vitamin B12 Levels, and Systemic Immune-Inflammation Index Correlate With Motor Performance in Parkinson's Disease: A Cross-Sectional Study
This study aimed to investigate the influence of serum folate, vitamin B12 (VitB12) levels, and inflammation-based scores on the motor performance status in Parkinson's disease (PD). We retrospectively collected data from 148 consecutive patients with idiopathic PD first admitted to our hospita...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8175849/ https://www.ncbi.nlm.nih.gov/pubmed/34093411 http://dx.doi.org/10.3389/fneur.2021.665075 |
_version_ | 1783703134087938048 |
---|---|
author | Li, Siying Zhang, Qingxi Gao, Yuyuan Nie, Kun Liang, Yanling Zhang, Yuhu Wang, Lijuan |
author_facet | Li, Siying Zhang, Qingxi Gao, Yuyuan Nie, Kun Liang, Yanling Zhang, Yuhu Wang, Lijuan |
author_sort | Li, Siying |
collection | PubMed |
description | This study aimed to investigate the influence of serum folate, vitamin B12 (VitB12) levels, and inflammation-based scores on the motor performance status in Parkinson's disease (PD). We retrospectively collected data from 148 consecutive patients with idiopathic PD first admitted to our hospital. We measured whole blood count, albumin, lactate dehydrogenase, C-reactive protein, folate, and VitB12 levels and calculated the inflammation-based scores. The following scales were applied to assess the motor performance status: activity of daily living scale (ADL, the Barthel Index), the Unified Parkinson's Disease Rating Scale Part III (UPDRS-III), and Hoehn–Yahr (H–Y) classification. The geometric mean of folate and VitB12 levels were 11.87 (ng/ml) and 330.52 (pmol/L), respectively. Folate deficiency (serum level < 4.0 ng/ml) and VitB12 deficiency (serum level < 133 pg/ml) were present in 0.7 and 5.4% of the patients, respectively. The mean prognostic nutritional index (PNI) and systemic immune-inflammation index (SII) were 47.78 ± 4.42 and 470.81 ± 254.05, respectively. The multivariate analyses showed that serum VitB12 level (P = 0.002) and SII (P = 0.005) were significant factors for ADL score; serum folate (P = 0.027) and VitB12 (P = 0.037) levels for UPDRS-III score; and serum folate (P = 0.066) and VitB12 (P = 0.017) levels for H–Y classification. The elevated folate level did correlate with greater decline in UPDRS-III score (P = 0.023) and H–Y classification (P = 0.003), whereas there was an obvious increase in ADL score (P = 0.048). SII was negatively associated (P < 0.001) with the ADL score. The three-dimensional drawing, combined with the effect of folate and VitB12 levels, showed that the lowest level of folate was associated with the lowest ADL score and the highest UPDRS-III score and H–Y classification. This study indicates that serum folate, VitB12 levels, and SII are significant factors influencing the motor performance status in patients with PD. SII is negatively associated with ADL. Elevated serum folate level correlates with mild motor impairment in patients with PD. |
format | Online Article Text |
id | pubmed-8175849 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-81758492021-06-05 Serum Folate, Vitamin B12 Levels, and Systemic Immune-Inflammation Index Correlate With Motor Performance in Parkinson's Disease: A Cross-Sectional Study Li, Siying Zhang, Qingxi Gao, Yuyuan Nie, Kun Liang, Yanling Zhang, Yuhu Wang, Lijuan Front Neurol Neurology This study aimed to investigate the influence of serum folate, vitamin B12 (VitB12) levels, and inflammation-based scores on the motor performance status in Parkinson's disease (PD). We retrospectively collected data from 148 consecutive patients with idiopathic PD first admitted to our hospital. We measured whole blood count, albumin, lactate dehydrogenase, C-reactive protein, folate, and VitB12 levels and calculated the inflammation-based scores. The following scales were applied to assess the motor performance status: activity of daily living scale (ADL, the Barthel Index), the Unified Parkinson's Disease Rating Scale Part III (UPDRS-III), and Hoehn–Yahr (H–Y) classification. The geometric mean of folate and VitB12 levels were 11.87 (ng/ml) and 330.52 (pmol/L), respectively. Folate deficiency (serum level < 4.0 ng/ml) and VitB12 deficiency (serum level < 133 pg/ml) were present in 0.7 and 5.4% of the patients, respectively. The mean prognostic nutritional index (PNI) and systemic immune-inflammation index (SII) were 47.78 ± 4.42 and 470.81 ± 254.05, respectively. The multivariate analyses showed that serum VitB12 level (P = 0.002) and SII (P = 0.005) were significant factors for ADL score; serum folate (P = 0.027) and VitB12 (P = 0.037) levels for UPDRS-III score; and serum folate (P = 0.066) and VitB12 (P = 0.017) levels for H–Y classification. The elevated folate level did correlate with greater decline in UPDRS-III score (P = 0.023) and H–Y classification (P = 0.003), whereas there was an obvious increase in ADL score (P = 0.048). SII was negatively associated (P < 0.001) with the ADL score. The three-dimensional drawing, combined with the effect of folate and VitB12 levels, showed that the lowest level of folate was associated with the lowest ADL score and the highest UPDRS-III score and H–Y classification. This study indicates that serum folate, VitB12 levels, and SII are significant factors influencing the motor performance status in patients with PD. SII is negatively associated with ADL. Elevated serum folate level correlates with mild motor impairment in patients with PD. Frontiers Media S.A. 2021-05-21 /pmc/articles/PMC8175849/ /pubmed/34093411 http://dx.doi.org/10.3389/fneur.2021.665075 Text en Copyright © 2021 Li, Zhang, Gao, Nie, Liang, Zhang and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neurology Li, Siying Zhang, Qingxi Gao, Yuyuan Nie, Kun Liang, Yanling Zhang, Yuhu Wang, Lijuan Serum Folate, Vitamin B12 Levels, and Systemic Immune-Inflammation Index Correlate With Motor Performance in Parkinson's Disease: A Cross-Sectional Study |
title | Serum Folate, Vitamin B12 Levels, and Systemic Immune-Inflammation Index Correlate With Motor Performance in Parkinson's Disease: A Cross-Sectional Study |
title_full | Serum Folate, Vitamin B12 Levels, and Systemic Immune-Inflammation Index Correlate With Motor Performance in Parkinson's Disease: A Cross-Sectional Study |
title_fullStr | Serum Folate, Vitamin B12 Levels, and Systemic Immune-Inflammation Index Correlate With Motor Performance in Parkinson's Disease: A Cross-Sectional Study |
title_full_unstemmed | Serum Folate, Vitamin B12 Levels, and Systemic Immune-Inflammation Index Correlate With Motor Performance in Parkinson's Disease: A Cross-Sectional Study |
title_short | Serum Folate, Vitamin B12 Levels, and Systemic Immune-Inflammation Index Correlate With Motor Performance in Parkinson's Disease: A Cross-Sectional Study |
title_sort | serum folate, vitamin b12 levels, and systemic immune-inflammation index correlate with motor performance in parkinson's disease: a cross-sectional study |
topic | Neurology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8175849/ https://www.ncbi.nlm.nih.gov/pubmed/34093411 http://dx.doi.org/10.3389/fneur.2021.665075 |
work_keys_str_mv | AT lisiying serumfolatevitaminb12levelsandsystemicimmuneinflammationindexcorrelatewithmotorperformanceinparkinsonsdiseaseacrosssectionalstudy AT zhangqingxi serumfolatevitaminb12levelsandsystemicimmuneinflammationindexcorrelatewithmotorperformanceinparkinsonsdiseaseacrosssectionalstudy AT gaoyuyuan serumfolatevitaminb12levelsandsystemicimmuneinflammationindexcorrelatewithmotorperformanceinparkinsonsdiseaseacrosssectionalstudy AT niekun serumfolatevitaminb12levelsandsystemicimmuneinflammationindexcorrelatewithmotorperformanceinparkinsonsdiseaseacrosssectionalstudy AT liangyanling serumfolatevitaminb12levelsandsystemicimmuneinflammationindexcorrelatewithmotorperformanceinparkinsonsdiseaseacrosssectionalstudy AT zhangyuhu serumfolatevitaminb12levelsandsystemicimmuneinflammationindexcorrelatewithmotorperformanceinparkinsonsdiseaseacrosssectionalstudy AT wanglijuan serumfolatevitaminb12levelsandsystemicimmuneinflammationindexcorrelatewithmotorperformanceinparkinsonsdiseaseacrosssectionalstudy |