Cargando…

Serum Folate, Vitamin B12 Levels, and Systemic Immune-Inflammation Index Correlate With Motor Performance in Parkinson's Disease: A Cross-Sectional Study

This study aimed to investigate the influence of serum folate, vitamin B12 (VitB12) levels, and inflammation-based scores on the motor performance status in Parkinson's disease (PD). We retrospectively collected data from 148 consecutive patients with idiopathic PD first admitted to our hospita...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Siying, Zhang, Qingxi, Gao, Yuyuan, Nie, Kun, Liang, Yanling, Zhang, Yuhu, Wang, Lijuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8175849/
https://www.ncbi.nlm.nih.gov/pubmed/34093411
http://dx.doi.org/10.3389/fneur.2021.665075
_version_ 1783703134087938048
author Li, Siying
Zhang, Qingxi
Gao, Yuyuan
Nie, Kun
Liang, Yanling
Zhang, Yuhu
Wang, Lijuan
author_facet Li, Siying
Zhang, Qingxi
Gao, Yuyuan
Nie, Kun
Liang, Yanling
Zhang, Yuhu
Wang, Lijuan
author_sort Li, Siying
collection PubMed
description This study aimed to investigate the influence of serum folate, vitamin B12 (VitB12) levels, and inflammation-based scores on the motor performance status in Parkinson's disease (PD). We retrospectively collected data from 148 consecutive patients with idiopathic PD first admitted to our hospital. We measured whole blood count, albumin, lactate dehydrogenase, C-reactive protein, folate, and VitB12 levels and calculated the inflammation-based scores. The following scales were applied to assess the motor performance status: activity of daily living scale (ADL, the Barthel Index), the Unified Parkinson's Disease Rating Scale Part III (UPDRS-III), and Hoehn–Yahr (H–Y) classification. The geometric mean of folate and VitB12 levels were 11.87 (ng/ml) and 330.52 (pmol/L), respectively. Folate deficiency (serum level < 4.0 ng/ml) and VitB12 deficiency (serum level < 133 pg/ml) were present in 0.7 and 5.4% of the patients, respectively. The mean prognostic nutritional index (PNI) and systemic immune-inflammation index (SII) were 47.78 ± 4.42 and 470.81 ± 254.05, respectively. The multivariate analyses showed that serum VitB12 level (P = 0.002) and SII (P = 0.005) were significant factors for ADL score; serum folate (P = 0.027) and VitB12 (P = 0.037) levels for UPDRS-III score; and serum folate (P = 0.066) and VitB12 (P = 0.017) levels for H–Y classification. The elevated folate level did correlate with greater decline in UPDRS-III score (P = 0.023) and H–Y classification (P = 0.003), whereas there was an obvious increase in ADL score (P = 0.048). SII was negatively associated (P < 0.001) with the ADL score. The three-dimensional drawing, combined with the effect of folate and VitB12 levels, showed that the lowest level of folate was associated with the lowest ADL score and the highest UPDRS-III score and H–Y classification. This study indicates that serum folate, VitB12 levels, and SII are significant factors influencing the motor performance status in patients with PD. SII is negatively associated with ADL. Elevated serum folate level correlates with mild motor impairment in patients with PD.
format Online
Article
Text
id pubmed-8175849
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-81758492021-06-05 Serum Folate, Vitamin B12 Levels, and Systemic Immune-Inflammation Index Correlate With Motor Performance in Parkinson's Disease: A Cross-Sectional Study Li, Siying Zhang, Qingxi Gao, Yuyuan Nie, Kun Liang, Yanling Zhang, Yuhu Wang, Lijuan Front Neurol Neurology This study aimed to investigate the influence of serum folate, vitamin B12 (VitB12) levels, and inflammation-based scores on the motor performance status in Parkinson's disease (PD). We retrospectively collected data from 148 consecutive patients with idiopathic PD first admitted to our hospital. We measured whole blood count, albumin, lactate dehydrogenase, C-reactive protein, folate, and VitB12 levels and calculated the inflammation-based scores. The following scales were applied to assess the motor performance status: activity of daily living scale (ADL, the Barthel Index), the Unified Parkinson's Disease Rating Scale Part III (UPDRS-III), and Hoehn–Yahr (H–Y) classification. The geometric mean of folate and VitB12 levels were 11.87 (ng/ml) and 330.52 (pmol/L), respectively. Folate deficiency (serum level < 4.0 ng/ml) and VitB12 deficiency (serum level < 133 pg/ml) were present in 0.7 and 5.4% of the patients, respectively. The mean prognostic nutritional index (PNI) and systemic immune-inflammation index (SII) were 47.78 ± 4.42 and 470.81 ± 254.05, respectively. The multivariate analyses showed that serum VitB12 level (P = 0.002) and SII (P = 0.005) were significant factors for ADL score; serum folate (P = 0.027) and VitB12 (P = 0.037) levels for UPDRS-III score; and serum folate (P = 0.066) and VitB12 (P = 0.017) levels for H–Y classification. The elevated folate level did correlate with greater decline in UPDRS-III score (P = 0.023) and H–Y classification (P = 0.003), whereas there was an obvious increase in ADL score (P = 0.048). SII was negatively associated (P < 0.001) with the ADL score. The three-dimensional drawing, combined with the effect of folate and VitB12 levels, showed that the lowest level of folate was associated with the lowest ADL score and the highest UPDRS-III score and H–Y classification. This study indicates that serum folate, VitB12 levels, and SII are significant factors influencing the motor performance status in patients with PD. SII is negatively associated with ADL. Elevated serum folate level correlates with mild motor impairment in patients with PD. Frontiers Media S.A. 2021-05-21 /pmc/articles/PMC8175849/ /pubmed/34093411 http://dx.doi.org/10.3389/fneur.2021.665075 Text en Copyright © 2021 Li, Zhang, Gao, Nie, Liang, Zhang and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Li, Siying
Zhang, Qingxi
Gao, Yuyuan
Nie, Kun
Liang, Yanling
Zhang, Yuhu
Wang, Lijuan
Serum Folate, Vitamin B12 Levels, and Systemic Immune-Inflammation Index Correlate With Motor Performance in Parkinson's Disease: A Cross-Sectional Study
title Serum Folate, Vitamin B12 Levels, and Systemic Immune-Inflammation Index Correlate With Motor Performance in Parkinson's Disease: A Cross-Sectional Study
title_full Serum Folate, Vitamin B12 Levels, and Systemic Immune-Inflammation Index Correlate With Motor Performance in Parkinson's Disease: A Cross-Sectional Study
title_fullStr Serum Folate, Vitamin B12 Levels, and Systemic Immune-Inflammation Index Correlate With Motor Performance in Parkinson's Disease: A Cross-Sectional Study
title_full_unstemmed Serum Folate, Vitamin B12 Levels, and Systemic Immune-Inflammation Index Correlate With Motor Performance in Parkinson's Disease: A Cross-Sectional Study
title_short Serum Folate, Vitamin B12 Levels, and Systemic Immune-Inflammation Index Correlate With Motor Performance in Parkinson's Disease: A Cross-Sectional Study
title_sort serum folate, vitamin b12 levels, and systemic immune-inflammation index correlate with motor performance in parkinson's disease: a cross-sectional study
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8175849/
https://www.ncbi.nlm.nih.gov/pubmed/34093411
http://dx.doi.org/10.3389/fneur.2021.665075
work_keys_str_mv AT lisiying serumfolatevitaminb12levelsandsystemicimmuneinflammationindexcorrelatewithmotorperformanceinparkinsonsdiseaseacrosssectionalstudy
AT zhangqingxi serumfolatevitaminb12levelsandsystemicimmuneinflammationindexcorrelatewithmotorperformanceinparkinsonsdiseaseacrosssectionalstudy
AT gaoyuyuan serumfolatevitaminb12levelsandsystemicimmuneinflammationindexcorrelatewithmotorperformanceinparkinsonsdiseaseacrosssectionalstudy
AT niekun serumfolatevitaminb12levelsandsystemicimmuneinflammationindexcorrelatewithmotorperformanceinparkinsonsdiseaseacrosssectionalstudy
AT liangyanling serumfolatevitaminb12levelsandsystemicimmuneinflammationindexcorrelatewithmotorperformanceinparkinsonsdiseaseacrosssectionalstudy
AT zhangyuhu serumfolatevitaminb12levelsandsystemicimmuneinflammationindexcorrelatewithmotorperformanceinparkinsonsdiseaseacrosssectionalstudy
AT wanglijuan serumfolatevitaminb12levelsandsystemicimmuneinflammationindexcorrelatewithmotorperformanceinparkinsonsdiseaseacrosssectionalstudy