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Effects of Genetic Polymorphism in CYP2D6, CYP2C19, and the Organic Cation Transporter OCT1 on Amitriptyline Pharmacokinetics in Healthy Volunteers and Depressive Disorder Patients

The tricyclic antidepressant amitriptyline is frequently prescribed but its use is limited by its narrow therapeutic range and large variation in pharmacokinetics. Apart from interindividual differences in the activity of the metabolising enzymes cytochrome P450 (CYP) 2D6 and 2C19, genetic polymorph...

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Detalles Bibliográficos
Autores principales:	Matthaei, Johannes, Brockmöller, Jürgen, Steimer, Werner, Pischa, Konstanze, Leucht, Stefan, Kullmann, Maria, Jensen, Ole, Ouethy, Typhaine, Tzvetkov, Mladen Vassilev, Rafehi, Muhammad
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8175851/ https://www.ncbi.nlm.nih.gov/pubmed/34093211 http://dx.doi.org/10.3389/fphar.2021.688950

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