The Role of Microtubules in Pancreatic Cancer: Therapeutic Progress

Pancreatic cancer has an extremely low prognosis, which is attributable to its high aggressiveness, invasiveness, late diagnosis, and lack of effective therapies. Among all the drugs joining the fight against this type of cancer, microtubule-targeting agents are considered to be the most promising....

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Autores principales: Albahde, Mugahed Abdullah Hasan, Abdrakhimov, Bulat, Li, Guo-Qi, Zhou, Xiaohu, Zhou, Dongkai, Xu, Hao, Qian, Huixiao, Wang, Weilin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8176010/
https://www.ncbi.nlm.nih.gov/pubmed/34094924
http://dx.doi.org/10.3389/fonc.2021.640863
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author Albahde, Mugahed Abdullah Hasan
Abdrakhimov, Bulat
Li, Guo-Qi
Zhou, Xiaohu
Zhou, Dongkai
Xu, Hao
Qian, Huixiao
Wang, Weilin
author_facet Albahde, Mugahed Abdullah Hasan
Abdrakhimov, Bulat
Li, Guo-Qi
Zhou, Xiaohu
Zhou, Dongkai
Xu, Hao
Qian, Huixiao
Wang, Weilin
author_sort Albahde, Mugahed Abdullah Hasan
collection PubMed
description Pancreatic cancer has an extremely low prognosis, which is attributable to its high aggressiveness, invasiveness, late diagnosis, and lack of effective therapies. Among all the drugs joining the fight against this type of cancer, microtubule-targeting agents are considered to be the most promising. They inhibit cancer cells although through different mechanisms such as blocking cell division, apoptosis induction, etc. Hereby, we review the functions of microtubule cytoskeletal proteins in tumor cells and comprehensively examine the effects of microtubule-targeting agents on pancreatic carcinoma.
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spelling pubmed-81760102021-06-05 The Role of Microtubules in Pancreatic Cancer: Therapeutic Progress Albahde, Mugahed Abdullah Hasan Abdrakhimov, Bulat Li, Guo-Qi Zhou, Xiaohu Zhou, Dongkai Xu, Hao Qian, Huixiao Wang, Weilin Front Oncol Oncology Pancreatic cancer has an extremely low prognosis, which is attributable to its high aggressiveness, invasiveness, late diagnosis, and lack of effective therapies. Among all the drugs joining the fight against this type of cancer, microtubule-targeting agents are considered to be the most promising. They inhibit cancer cells although through different mechanisms such as blocking cell division, apoptosis induction, etc. Hereby, we review the functions of microtubule cytoskeletal proteins in tumor cells and comprehensively examine the effects of microtubule-targeting agents on pancreatic carcinoma. Frontiers Media S.A. 2021-05-21 /pmc/articles/PMC8176010/ /pubmed/34094924 http://dx.doi.org/10.3389/fonc.2021.640863 Text en Copyright © 2021 Albahde, Abdrakhimov, Li, Zhou, Zhou, Xu, Qian and Wang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Albahde, Mugahed Abdullah Hasan
Abdrakhimov, Bulat
Li, Guo-Qi
Zhou, Xiaohu
Zhou, Dongkai
Xu, Hao
Qian, Huixiao
Wang, Weilin
The Role of Microtubules in Pancreatic Cancer: Therapeutic Progress
title The Role of Microtubules in Pancreatic Cancer: Therapeutic Progress
title_full The Role of Microtubules in Pancreatic Cancer: Therapeutic Progress
title_fullStr The Role of Microtubules in Pancreatic Cancer: Therapeutic Progress
title_full_unstemmed The Role of Microtubules in Pancreatic Cancer: Therapeutic Progress
title_short The Role of Microtubules in Pancreatic Cancer: Therapeutic Progress
title_sort role of microtubules in pancreatic cancer: therapeutic progress
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8176010/
https://www.ncbi.nlm.nih.gov/pubmed/34094924
http://dx.doi.org/10.3389/fonc.2021.640863
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