Reduced Expression of GABA(A) Receptor Alpha2 Subunit Is Associated With Disinhibition of DYT-THAP1 Dystonia Patient-Derived Striatal Medium Spiny Neurons

DYT-THAP1 dystonia (formerly DYT6) is an adolescent-onset dystonia characterized by involuntary muscle contractions usually involving the upper body. It is caused by mutations in the gene THAP1 encoding for the transcription factor Thanatos-associated protein (THAP) domain containing apoptosis-assoc...

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Detalles Bibliográficos
Autores principales: Staege, Selma, Kutschenko, Anna, Baumann, Hauke, Glaß, Hannes, Henkel, Lisa, Gschwendtberger, Thomas, Kalmbach, Norman, Klietz, Martin, Hermann, Andreas, Lohmann, Katja, Seibler, Philip, Wegner, Florian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8176025/
https://www.ncbi.nlm.nih.gov/pubmed/34095114
http://dx.doi.org/10.3389/fcell.2021.650586

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