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Role of a metastatic suppressor gene KAI1/CD82 in the diagnosis and prognosis of breast cancer
Globally, breast cancer is the most common type of cancer in females and is one of the leading causes of cancer death in women. The advancement in the targeted therapies and the slight understanding of the molecular cascades of the disease have led to small improvement in the rate of survival of bre...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8176039/ https://www.ncbi.nlm.nih.gov/pubmed/34121877 http://dx.doi.org/10.1016/j.sjbs.2021.03.001 |
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author | Al-Khater, Khulood M. Almofty, Sarah Ravinayagam, Vijaya Alrushaid, Noor Rehman, Suriya |
author_facet | Al-Khater, Khulood M. Almofty, Sarah Ravinayagam, Vijaya Alrushaid, Noor Rehman, Suriya |
author_sort | Al-Khater, Khulood M. |
collection | PubMed |
description | Globally, breast cancer is the most common type of cancer in females and is one of the leading causes of cancer death in women. The advancement in the targeted therapies and the slight understanding of the molecular cascades of the disease have led to small improvement in the rate of survival of breast cancer patients. However, metastasis and resistance to the current drugs still remain as challenges in the management of breast cancer patients. Metastasis, potentially, leads to failure of the available treatment, and thereby, makes the research on metastatic suppressors a high priority. Tumor metastasis suppressors are several genes and their protein products that have the capability of arresting the metastatic process without affecting the tumor formation. The metastasis suppressors KAI1 (also known as CD82) has been found to inhibit tumor metastasis in various types of solid cancers, including breast cancer. KAI1 was identified as a metastasis suppressor that inhibits the process of metastasis by regulating several mechanisms, including cell motility and invasion, induction of cell senescence, cell–cell adhesion and apoptosis. KAI1 is a member of tetraspanin membrane protein family. It interacts with other tetraspanins, chemokines and integrins to control diverse signaling pathways, which are crucial for protein trafficking and intracellular communication. It follows that better understanding of the molecular events of such genes is needed to develop prognostic biomarkers, and to identify specific therapies for breast cancer patients. This review aims to discuss the role of KAI1/CD82 as a prognosticator in breast cancer. |
format | Online Article Text |
id | pubmed-8176039 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-81760392021-06-11 Role of a metastatic suppressor gene KAI1/CD82 in the diagnosis and prognosis of breast cancer Al-Khater, Khulood M. Almofty, Sarah Ravinayagam, Vijaya Alrushaid, Noor Rehman, Suriya Saudi J Biol Sci Review Globally, breast cancer is the most common type of cancer in females and is one of the leading causes of cancer death in women. The advancement in the targeted therapies and the slight understanding of the molecular cascades of the disease have led to small improvement in the rate of survival of breast cancer patients. However, metastasis and resistance to the current drugs still remain as challenges in the management of breast cancer patients. Metastasis, potentially, leads to failure of the available treatment, and thereby, makes the research on metastatic suppressors a high priority. Tumor metastasis suppressors are several genes and their protein products that have the capability of arresting the metastatic process without affecting the tumor formation. The metastasis suppressors KAI1 (also known as CD82) has been found to inhibit tumor metastasis in various types of solid cancers, including breast cancer. KAI1 was identified as a metastasis suppressor that inhibits the process of metastasis by regulating several mechanisms, including cell motility and invasion, induction of cell senescence, cell–cell adhesion and apoptosis. KAI1 is a member of tetraspanin membrane protein family. It interacts with other tetraspanins, chemokines and integrins to control diverse signaling pathways, which are crucial for protein trafficking and intracellular communication. It follows that better understanding of the molecular events of such genes is needed to develop prognostic biomarkers, and to identify specific therapies for breast cancer patients. This review aims to discuss the role of KAI1/CD82 as a prognosticator in breast cancer. Elsevier 2021-06 2021-03-10 /pmc/articles/PMC8176039/ /pubmed/34121877 http://dx.doi.org/10.1016/j.sjbs.2021.03.001 Text en © 2021 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Al-Khater, Khulood M. Almofty, Sarah Ravinayagam, Vijaya Alrushaid, Noor Rehman, Suriya Role of a metastatic suppressor gene KAI1/CD82 in the diagnosis and prognosis of breast cancer |
title | Role of a metastatic suppressor gene KAI1/CD82 in the diagnosis and prognosis of breast cancer |
title_full | Role of a metastatic suppressor gene KAI1/CD82 in the diagnosis and prognosis of breast cancer |
title_fullStr | Role of a metastatic suppressor gene KAI1/CD82 in the diagnosis and prognosis of breast cancer |
title_full_unstemmed | Role of a metastatic suppressor gene KAI1/CD82 in the diagnosis and prognosis of breast cancer |
title_short | Role of a metastatic suppressor gene KAI1/CD82 in the diagnosis and prognosis of breast cancer |
title_sort | role of a metastatic suppressor gene kai1/cd82 in the diagnosis and prognosis of breast cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8176039/ https://www.ncbi.nlm.nih.gov/pubmed/34121877 http://dx.doi.org/10.1016/j.sjbs.2021.03.001 |
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