Characterization of B- and T-Cell Compartment and B-Cell Related Factors Belonging to the TNF/TNFR Superfamily in Patients With Clinically Active Systemic Lupus Erythematosus: Baseline BAFF Serum Levels Are the Strongest Predictor of Response to Belimumab after Twelve Months of Therapy

Background: Patients with systemic lupus erythematosus (SLE) show increased serum levels of tumor necrosis factor (TNF)/TNF receptor (R) superfamily member, e.g. BAFF (B lymphocyte stimulator). Belimumab, a monoclonal antibody against soluble BAFF, is used for treatment of SLE. Although B cells are...

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Detalles Bibliográficos
Autores principales: Piantoni, Silvia, Regola, Francesca, Masneri, Stefania, Merletti, Michele, Lowin, Torsten, Airò, Paolo, Tincani, Angela, Franceschini, Franco, Andreoli, Laura, Pongratz, Georg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8176088/
https://www.ncbi.nlm.nih.gov/pubmed/34093196
http://dx.doi.org/10.3389/fphar.2021.666971

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