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Dynamic Observation of the Effect of Maternal Caries on the Oral Microbiota of Infants Aged 12–24 Months

AIM: To provide a dynamic description of the oral microbial composition in mothers with and without dental caries and their children aging 12-24 months. METHODOLOGY: A total of 20 pairs of mothers and their children aged 12 months were included and followed up at 18 and 24 months of age. Ten mothers...

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Autores principales: Li, Fei, Fu, Ding, Tao, Danying, Feng, Xiping, Wong, May Chun Mei, Xu, Wei, Lu, Haixia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8176096/
https://www.ncbi.nlm.nih.gov/pubmed/34094997
http://dx.doi.org/10.3389/fcimb.2021.637394
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author Li, Fei
Fu, Ding
Tao, Danying
Feng, Xiping
Wong, May Chun Mei
Xu, Wei
Lu, Haixia
author_facet Li, Fei
Fu, Ding
Tao, Danying
Feng, Xiping
Wong, May Chun Mei
Xu, Wei
Lu, Haixia
author_sort Li, Fei
collection PubMed
description AIM: To provide a dynamic description of the oral microbial composition in mothers with and without dental caries and their children aging 12-24 months. METHODOLOGY: A total of 20 pairs of mothers and their children aged 12 months were included and followed up at 18 and 24 months of age. Ten mothers with dental caries(MEG) and their children(CEG) were in the exposure group, and ten caries-free mothers(MCG) and their children(CCG)in control group. Supragingival plaque biofilm samples were collected and DNA was extracted for bacterial 16S rRNA gene sequencing. RESULTS: A total of 18 pairs completed follow-ups. At a 3% divergence level, the number of common operational taxonomic units found between the mothers and children increased as the children aged. Proteobacteria, Bacteroidetes, Firmicutes, Fusobacteria, and Actinobacteria accounted for more than 80% phyla of each group. A microbial community structure analysis showed that the differences between mothers and children were significant in all groups except for the MEG24 and CEG24 groups. CONCLUSIONS: Oral microbiota of children was more like their mothers’ with increasing age, regardless of whether the mothers had dental caries. Mothers with dental caries may have a greater influence on the oral microbiota of children’s than those without dental caries as children age.
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spelling pubmed-81760962021-06-05 Dynamic Observation of the Effect of Maternal Caries on the Oral Microbiota of Infants Aged 12–24 Months Li, Fei Fu, Ding Tao, Danying Feng, Xiping Wong, May Chun Mei Xu, Wei Lu, Haixia Front Cell Infect Microbiol Cellular and Infection Microbiology AIM: To provide a dynamic description of the oral microbial composition in mothers with and without dental caries and their children aging 12-24 months. METHODOLOGY: A total of 20 pairs of mothers and their children aged 12 months were included and followed up at 18 and 24 months of age. Ten mothers with dental caries(MEG) and their children(CEG) were in the exposure group, and ten caries-free mothers(MCG) and their children(CCG)in control group. Supragingival plaque biofilm samples were collected and DNA was extracted for bacterial 16S rRNA gene sequencing. RESULTS: A total of 18 pairs completed follow-ups. At a 3% divergence level, the number of common operational taxonomic units found between the mothers and children increased as the children aged. Proteobacteria, Bacteroidetes, Firmicutes, Fusobacteria, and Actinobacteria accounted for more than 80% phyla of each group. A microbial community structure analysis showed that the differences between mothers and children were significant in all groups except for the MEG24 and CEG24 groups. CONCLUSIONS: Oral microbiota of children was more like their mothers’ with increasing age, regardless of whether the mothers had dental caries. Mothers with dental caries may have a greater influence on the oral microbiota of children’s than those without dental caries as children age. Frontiers Media S.A. 2021-05-21 /pmc/articles/PMC8176096/ /pubmed/34094997 http://dx.doi.org/10.3389/fcimb.2021.637394 Text en Copyright © 2021 Li, Fu, Tao, Feng, Wong, Xu and Lu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Li, Fei
Fu, Ding
Tao, Danying
Feng, Xiping
Wong, May Chun Mei
Xu, Wei
Lu, Haixia
Dynamic Observation of the Effect of Maternal Caries on the Oral Microbiota of Infants Aged 12–24 Months
title Dynamic Observation of the Effect of Maternal Caries on the Oral Microbiota of Infants Aged 12–24 Months
title_full Dynamic Observation of the Effect of Maternal Caries on the Oral Microbiota of Infants Aged 12–24 Months
title_fullStr Dynamic Observation of the Effect of Maternal Caries on the Oral Microbiota of Infants Aged 12–24 Months
title_full_unstemmed Dynamic Observation of the Effect of Maternal Caries on the Oral Microbiota of Infants Aged 12–24 Months
title_short Dynamic Observation of the Effect of Maternal Caries on the Oral Microbiota of Infants Aged 12–24 Months
title_sort dynamic observation of the effect of maternal caries on the oral microbiota of infants aged 12–24 months
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8176096/
https://www.ncbi.nlm.nih.gov/pubmed/34094997
http://dx.doi.org/10.3389/fcimb.2021.637394
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