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Elevated plasma level of neutrophil gelatinase-associated lipocalin (NGAL) in patients with breast cancer

Background: Neutrophil gelatinase‑associated lipocalin (NGAL), also known as lipocalin 2, siderocalin, 24p3 or uterocalin, plays a key role in inflammation and in different types of cancer. In this study, we investigated whether plasma NGAL levels were altered in patients with breast cancer. The rel...

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Autores principales: Wei, Ching-Ting, Tsai, I-Ting, Wu, Cheng-Ching, Hung, Wei-Chin, Hsuan, Chin-Feng, Yu, Teng-Hung, Hsu, Chia-Chang, Houng, Jer-Yiing, Chung, Fu-Mei, Lee, Yau-Jiunn, Lu, Yung-Chuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8176172/
https://www.ncbi.nlm.nih.gov/pubmed/34104101
http://dx.doi.org/10.7150/ijms.58789
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author Wei, Ching-Ting
Tsai, I-Ting
Wu, Cheng-Ching
Hung, Wei-Chin
Hsuan, Chin-Feng
Yu, Teng-Hung
Hsu, Chia-Chang
Houng, Jer-Yiing
Chung, Fu-Mei
Lee, Yau-Jiunn
Lu, Yung-Chuan
author_facet Wei, Ching-Ting
Tsai, I-Ting
Wu, Cheng-Ching
Hung, Wei-Chin
Hsuan, Chin-Feng
Yu, Teng-Hung
Hsu, Chia-Chang
Houng, Jer-Yiing
Chung, Fu-Mei
Lee, Yau-Jiunn
Lu, Yung-Chuan
author_sort Wei, Ching-Ting
collection PubMed
description Background: Neutrophil gelatinase‑associated lipocalin (NGAL), also known as lipocalin 2, siderocalin, 24p3 or uterocalin, plays a key role in inflammation and in different types of cancer. In this study, we investigated whether plasma NGAL levels were altered in patients with breast cancer. The relationship between plasma NGAL levels and pretreatment hematologic profile was also explored. Methods: Plasma NGAL concentrations were measured using ELISA in breast cancer patients and control subjects. A total of 75 patients with breast cancer and 65 age- and body mass index-matched control subjects were studied. All of the study subjects were female. Results: Plasma NGAL level was found to be elevated in the patients with breast cancer compared to the control subjects (94.3 ng/mL (interquartile range 39.3-207.6) vs. 55.0 ng/mL (interquartile range 25.8-124.7), p = 0.007). Multiple logistic regression analysis revealed that NGAL was independently associated with breast cancer, even after adjusting for known biomarkers. Furthermore, NGAL level was elevated in the breast cancer patients who were negative progesterone receptor status, had a histologic grade ≥ 2, clinical stage III, and pathologic stage T2+T3+T4. In addition, NGAL level was significantly correlated with white blood cell (WBC) count, monocyte count, neutrophil count, and platelet count (all p < 0.01). Moreover, WBC count, neutrophil count, monocyte count, lymphocyte count, platelet count, and NGAL level gradually increased as the stage progressed. Conclusions: Increased plasma NGAL levels were associated with breast cancer independently of risk factors, and were correlated with inflammatory biomarkers. These results suggest that NGAL may act through inflammatory reactions to play an important role in the pathogenesis of breast cancer.
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spelling pubmed-81761722021-06-07 Elevated plasma level of neutrophil gelatinase-associated lipocalin (NGAL) in patients with breast cancer Wei, Ching-Ting Tsai, I-Ting Wu, Cheng-Ching Hung, Wei-Chin Hsuan, Chin-Feng Yu, Teng-Hung Hsu, Chia-Chang Houng, Jer-Yiing Chung, Fu-Mei Lee, Yau-Jiunn Lu, Yung-Chuan Int J Med Sci Research Paper Background: Neutrophil gelatinase‑associated lipocalin (NGAL), also known as lipocalin 2, siderocalin, 24p3 or uterocalin, plays a key role in inflammation and in different types of cancer. In this study, we investigated whether plasma NGAL levels were altered in patients with breast cancer. The relationship between plasma NGAL levels and pretreatment hematologic profile was also explored. Methods: Plasma NGAL concentrations were measured using ELISA in breast cancer patients and control subjects. A total of 75 patients with breast cancer and 65 age- and body mass index-matched control subjects were studied. All of the study subjects were female. Results: Plasma NGAL level was found to be elevated in the patients with breast cancer compared to the control subjects (94.3 ng/mL (interquartile range 39.3-207.6) vs. 55.0 ng/mL (interquartile range 25.8-124.7), p = 0.007). Multiple logistic regression analysis revealed that NGAL was independently associated with breast cancer, even after adjusting for known biomarkers. Furthermore, NGAL level was elevated in the breast cancer patients who were negative progesterone receptor status, had a histologic grade ≥ 2, clinical stage III, and pathologic stage T2+T3+T4. In addition, NGAL level was significantly correlated with white blood cell (WBC) count, monocyte count, neutrophil count, and platelet count (all p < 0.01). Moreover, WBC count, neutrophil count, monocyte count, lymphocyte count, platelet count, and NGAL level gradually increased as the stage progressed. Conclusions: Increased plasma NGAL levels were associated with breast cancer independently of risk factors, and were correlated with inflammatory biomarkers. These results suggest that NGAL may act through inflammatory reactions to play an important role in the pathogenesis of breast cancer. Ivyspring International Publisher 2021-05-13 /pmc/articles/PMC8176172/ /pubmed/34104101 http://dx.doi.org/10.7150/ijms.58789 Text en © The author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Wei, Ching-Ting
Tsai, I-Ting
Wu, Cheng-Ching
Hung, Wei-Chin
Hsuan, Chin-Feng
Yu, Teng-Hung
Hsu, Chia-Chang
Houng, Jer-Yiing
Chung, Fu-Mei
Lee, Yau-Jiunn
Lu, Yung-Chuan
Elevated plasma level of neutrophil gelatinase-associated lipocalin (NGAL) in patients with breast cancer
title Elevated plasma level of neutrophil gelatinase-associated lipocalin (NGAL) in patients with breast cancer
title_full Elevated plasma level of neutrophil gelatinase-associated lipocalin (NGAL) in patients with breast cancer
title_fullStr Elevated plasma level of neutrophil gelatinase-associated lipocalin (NGAL) in patients with breast cancer
title_full_unstemmed Elevated plasma level of neutrophil gelatinase-associated lipocalin (NGAL) in patients with breast cancer
title_short Elevated plasma level of neutrophil gelatinase-associated lipocalin (NGAL) in patients with breast cancer
title_sort elevated plasma level of neutrophil gelatinase-associated lipocalin (ngal) in patients with breast cancer
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8176172/
https://www.ncbi.nlm.nih.gov/pubmed/34104101
http://dx.doi.org/10.7150/ijms.58789
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