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A severe case of human coronavirus 229E pneumonia in an elderly man with diabetes mellitus: a case report

BACKGROUND: With pandemic of coronavirus disease 2019 (COVID-19), human coronaviruses (HCoVs) have recently attached worldwide attention as essential pathogens in respiratory infection. HCoV-229E has been described as a rare cause of lower respiratory infection in immunocompetent adults. CASE PRESEN...

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Autores principales: Sun, Wen, Liao, Ji-Ping, Yu, Kun-Yao, Qiu, Jian-Xing, Que, Chen-Li, Wang, Guang-Fa, Ma, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8176273/
https://www.ncbi.nlm.nih.gov/pubmed/34088268
http://dx.doi.org/10.1186/s12879-021-06188-3
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author Sun, Wen
Liao, Ji-Ping
Yu, Kun-Yao
Qiu, Jian-Xing
Que, Chen-Li
Wang, Guang-Fa
Ma, Jing
author_facet Sun, Wen
Liao, Ji-Ping
Yu, Kun-Yao
Qiu, Jian-Xing
Que, Chen-Li
Wang, Guang-Fa
Ma, Jing
author_sort Sun, Wen
collection PubMed
description BACKGROUND: With pandemic of coronavirus disease 2019 (COVID-19), human coronaviruses (HCoVs) have recently attached worldwide attention as essential pathogens in respiratory infection. HCoV-229E has been described as a rare cause of lower respiratory infection in immunocompetent adults. CASE PRESENTATION: We reported a 72-year-old man infected by HCoV-229E with rapid progression to acute respiratory distress syndrome, in conjunction with new onset atrial fibrillation, intensive care unit acquired weakness, and recurrent hospital acquired pneumonia. Clinical and radiological data were continuously collected. The absolute number of peripheral T cells and the level of complement components diminished initially and recovered after 2 months. The patient was successfully treated under intensive support care and discharged from the hospital after 3 months and followed. CONCLUSION: HCoV-229E might an essential causative agent of pulmonary inflammation and extensive lung damage. Supportive treatment was essential to HCoVs infection on account of a long duration of immunological recovery in critical HCoV-229E infection.
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spelling pubmed-81762732021-06-04 A severe case of human coronavirus 229E pneumonia in an elderly man with diabetes mellitus: a case report Sun, Wen Liao, Ji-Ping Yu, Kun-Yao Qiu, Jian-Xing Que, Chen-Li Wang, Guang-Fa Ma, Jing BMC Infect Dis Case Report BACKGROUND: With pandemic of coronavirus disease 2019 (COVID-19), human coronaviruses (HCoVs) have recently attached worldwide attention as essential pathogens in respiratory infection. HCoV-229E has been described as a rare cause of lower respiratory infection in immunocompetent adults. CASE PRESENTATION: We reported a 72-year-old man infected by HCoV-229E with rapid progression to acute respiratory distress syndrome, in conjunction with new onset atrial fibrillation, intensive care unit acquired weakness, and recurrent hospital acquired pneumonia. Clinical and radiological data were continuously collected. The absolute number of peripheral T cells and the level of complement components diminished initially and recovered after 2 months. The patient was successfully treated under intensive support care and discharged from the hospital after 3 months and followed. CONCLUSION: HCoV-229E might an essential causative agent of pulmonary inflammation and extensive lung damage. Supportive treatment was essential to HCoVs infection on account of a long duration of immunological recovery in critical HCoV-229E infection. BioMed Central 2021-06-04 /pmc/articles/PMC8176273/ /pubmed/34088268 http://dx.doi.org/10.1186/s12879-021-06188-3 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Case Report
Sun, Wen
Liao, Ji-Ping
Yu, Kun-Yao
Qiu, Jian-Xing
Que, Chen-Li
Wang, Guang-Fa
Ma, Jing
A severe case of human coronavirus 229E pneumonia in an elderly man with diabetes mellitus: a case report
title A severe case of human coronavirus 229E pneumonia in an elderly man with diabetes mellitus: a case report
title_full A severe case of human coronavirus 229E pneumonia in an elderly man with diabetes mellitus: a case report
title_fullStr A severe case of human coronavirus 229E pneumonia in an elderly man with diabetes mellitus: a case report
title_full_unstemmed A severe case of human coronavirus 229E pneumonia in an elderly man with diabetes mellitus: a case report
title_short A severe case of human coronavirus 229E pneumonia in an elderly man with diabetes mellitus: a case report
title_sort severe case of human coronavirus 229e pneumonia in an elderly man with diabetes mellitus: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8176273/
https://www.ncbi.nlm.nih.gov/pubmed/34088268
http://dx.doi.org/10.1186/s12879-021-06188-3
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