CRISPR-Cas9-Based Discovery of the Verrucosidin Biosynthesis Gene Cluster in Penicillium polonicum

Penicillium polonicum, commonly found on food matrices, is a mycotoxigenic species able to produce a neurotoxin called verrucosidin. This methylated α-pyrone polyketide inhibits oxidative phosphorylation in mitochondria and thereby causes neurological diseases. Despite the importance of verrucosidin...

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Detalles Bibliográficos
Autores principales: Valente, Silvia, Piombo, Edoardo, Schroeckh, Volker, Meloni, Giovanna Roberta, Heinekamp, Thorsten, Brakhage, Axel A., Spadaro, Davide
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8176439/
https://www.ncbi.nlm.nih.gov/pubmed/34093475
http://dx.doi.org/10.3389/fmicb.2021.660871

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8176439/
https://www.ncbi.nlm.nih.gov/pubmed/34093475
http://dx.doi.org/10.3389/fmicb.2021.660871

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