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Case Report: Atypical Presentation of Visceral Leishmaniasis: Two Cases from Northwest Ethiopia
Human visceral leishmaniasis (VL) is a life-threatening disease caused by protozoan parasites belonging to the Leishmania donovani complex. Atypical cases of leishmaniasis and HIV coinfection have been documented in case reports, mostly associated with gastrointestinal tract, kidney, and skin involv...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The American Society of Tropical Medicine and Hygiene
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8176479/ https://www.ncbi.nlm.nih.gov/pubmed/33844644 http://dx.doi.org/10.4269/ajtmh.20-0666 |
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author | Mohammed, Rezika Fikre, Helina Mekonnen, Tigist Abebe, Bewketu Yeshanew, Arega Diro, Ermias van Griensven, Johan |
author_facet | Mohammed, Rezika Fikre, Helina Mekonnen, Tigist Abebe, Bewketu Yeshanew, Arega Diro, Ermias van Griensven, Johan |
author_sort | Mohammed, Rezika |
collection | PubMed |
description | Human visceral leishmaniasis (VL) is a life-threatening disease caused by protozoan parasites belonging to the Leishmania donovani complex. Atypical cases of leishmaniasis and HIV coinfection have been documented in case reports, mostly associated with gastrointestinal tract, kidney, and skin involvement. We report two VL cases with atypical localizations not reported from east Africa before, both diagnosed and treated at the Leishmaniasis Research and Treatment Center, Gondar, Ethiopia. The first case was an HIV-infected patient with scrotal and penile involvement. Leishmania parasites were detected in the spleen and the scrotum. The second case was an immunocompetent individual with esophageal, laryngeal, and pharyngeal involvement and facial lesions. Leishmania parasites were detected in the spleen, skin, and esophageal biopsies. Current evidence suggests atypical presentation can occur in patients irrespective of their HIV status. Therefore, we suggest a high index of suspicion for VL among clinicians working in endemic areas of Ethiopia. |
format | Online Article Text |
id | pubmed-8176479 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | The American Society of Tropical Medicine and Hygiene |
record_format | MEDLINE/PubMed |
spelling | pubmed-81764792021-06-07 Case Report: Atypical Presentation of Visceral Leishmaniasis: Two Cases from Northwest Ethiopia Mohammed, Rezika Fikre, Helina Mekonnen, Tigist Abebe, Bewketu Yeshanew, Arega Diro, Ermias van Griensven, Johan Am J Trop Med Hyg Articles Human visceral leishmaniasis (VL) is a life-threatening disease caused by protozoan parasites belonging to the Leishmania donovani complex. Atypical cases of leishmaniasis and HIV coinfection have been documented in case reports, mostly associated with gastrointestinal tract, kidney, and skin involvement. We report two VL cases with atypical localizations not reported from east Africa before, both diagnosed and treated at the Leishmaniasis Research and Treatment Center, Gondar, Ethiopia. The first case was an HIV-infected patient with scrotal and penile involvement. Leishmania parasites were detected in the spleen and the scrotum. The second case was an immunocompetent individual with esophageal, laryngeal, and pharyngeal involvement and facial lesions. Leishmania parasites were detected in the spleen, skin, and esophageal biopsies. Current evidence suggests atypical presentation can occur in patients irrespective of their HIV status. Therefore, we suggest a high index of suspicion for VL among clinicians working in endemic areas of Ethiopia. The American Society of Tropical Medicine and Hygiene 2021-06 2021-04-12 /pmc/articles/PMC8176479/ /pubmed/33844644 http://dx.doi.org/10.4269/ajtmh.20-0666 Text en © The American Society of Tropical Medicine and Hygiene https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution (CC-BY) License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Articles Mohammed, Rezika Fikre, Helina Mekonnen, Tigist Abebe, Bewketu Yeshanew, Arega Diro, Ermias van Griensven, Johan Case Report: Atypical Presentation of Visceral Leishmaniasis: Two Cases from Northwest Ethiopia |
title | Case Report: Atypical Presentation of Visceral Leishmaniasis: Two Cases from Northwest Ethiopia |
title_full | Case Report: Atypical Presentation of Visceral Leishmaniasis: Two Cases from Northwest Ethiopia |
title_fullStr | Case Report: Atypical Presentation of Visceral Leishmaniasis: Two Cases from Northwest Ethiopia |
title_full_unstemmed | Case Report: Atypical Presentation of Visceral Leishmaniasis: Two Cases from Northwest Ethiopia |
title_short | Case Report: Atypical Presentation of Visceral Leishmaniasis: Two Cases from Northwest Ethiopia |
title_sort | case report: atypical presentation of visceral leishmaniasis: two cases from northwest ethiopia |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8176479/ https://www.ncbi.nlm.nih.gov/pubmed/33844644 http://dx.doi.org/10.4269/ajtmh.20-0666 |
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