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Pharmacodynamic Correlates of Linezolid Activity and Toxicity in Murine Models of Tuberculosis

BACKGROUND: Linezolid (LZD) is bactericidal against Mycobacterium tuberculosis, but it has treatment-limiting toxicities. A better understanding of exposure-response relationships governing LZD efficacy and toxicity will inform dosing strategies. Because in vitro monotherapy studies yielded conflict...

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Detalles Bibliográficos
Autores principales:	Bigelow, Kristina M, Deitchman, Amelia N, Li, Si-Yang, Barnes-Boyle, Kala, Tyagi, Sandeep, Soni, Heena, Dooley, Kelly E, Savic, Rada M, Nuermberger, Eric L
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Major Articles and Brief Reports
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8176636/ https://www.ncbi.nlm.nih.gov/pubmed/31993638 http://dx.doi.org/10.1093/infdis/jiaa016

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