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The phosphatase Shp1 interacts with and dephosphorylates cortactin to inhibit invadopodia function

BACKGROUND: Invadopodia are actin-based cell-membrane protrusions associated with the extracellular matrix degradation accompanying cancer invasion. The elucidation of the molecular mechanisms leading to invadopodia formation and activity is central for the prevention of tumor spreading and growth....

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Detalles Bibliográficos
Autores principales:	Varone, Alessia, Amoruso, Chiara, Monti, Marcello, Patheja, Manpreet, Greco, Adelaide, Auletta, Luigi, Zannetti, Antonella, Corda, Daniela
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8176763/ https://www.ncbi.nlm.nih.gov/pubmed/34088320 http://dx.doi.org/10.1186/s12964-021-00747-6

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