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Preoperative Gadoxetic Acid-Enhanced MRI Based Nomogram Improves Prediction of Early HCC Recurrence After Ablation Therapy
PURPOSE: This study aimed to identify preoperative gadoxetic acid-enhanced MRI features and establish a nomogram for predicting early recurrence (≤ 2 years) of hepatocellular carcinoma (HCC) after ablation therapy. METHODS: A total of 160 patients who underwent gadoxetic acid-enhanced MRI and ablati...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8176857/ https://www.ncbi.nlm.nih.gov/pubmed/34094938 http://dx.doi.org/10.3389/fonc.2021.649682 |
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author | Hu, Chengguang Song, Yangda Zhang, Jing Dai, Lin Tang, Cuirong Li, Meng Liao, Weijia Zhou, Yuchen Xu, Yikai Zhang, Yong-Yuan Zhou, Yuanping |
author_facet | Hu, Chengguang Song, Yangda Zhang, Jing Dai, Lin Tang, Cuirong Li, Meng Liao, Weijia Zhou, Yuchen Xu, Yikai Zhang, Yong-Yuan Zhou, Yuanping |
author_sort | Hu, Chengguang |
collection | PubMed |
description | PURPOSE: This study aimed to identify preoperative gadoxetic acid-enhanced MRI features and establish a nomogram for predicting early recurrence (≤ 2 years) of hepatocellular carcinoma (HCC) after ablation therapy. METHODS: A total of 160 patients who underwent gadoxetic acid-enhanced MRI and ablation HCC therapy from January 2015 to June 2018, were included retrospectively and divided into a training cohort (n = 112) and a validation cohort (n = 48). Independent clinical risk factors and gadoxetic acid-enhanced MRI features associated with early recurrence were identified by univariate and multivariate logistic regression analysis and used for construction of a nomogram. The performance of the nomogram was evaluated by discrimination, calibration, and clinical utility. RESULTS: Alpha-fetoprotein (AFP) level, tumor number, arterial peritumoral enhancement, satellite nodule and peritumoral hypointensity at hepatobiliary phases in the training cohort were identified as independent risk factors for early recurrence after ablation. A new nomogram that was constructed with these five features showed an area under the curve (AUC) of 0.843 (95%CI 0.771-0.916) and 0.835 (95%CI 0.713-0.956) in the training and validation cohort, respectively. The calibration curve and decision curve analysis (DCA) suggested that the nomogram had good consistency and clinical utility. CONCLUSIONS: A new nomogram that was constructed using four preoperative gadoxetic acid-enhanced MRI features and serum AFP level can predict the risk of early HCC recurrence after ablation therapy with AUC up to 0.843. The strong performance of this nomogram may help hepatologists to categorize patients’ recurrent risk to guide selecting treatment options and improve postoperative management. |
format | Online Article Text |
id | pubmed-8176857 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-81768572021-06-05 Preoperative Gadoxetic Acid-Enhanced MRI Based Nomogram Improves Prediction of Early HCC Recurrence After Ablation Therapy Hu, Chengguang Song, Yangda Zhang, Jing Dai, Lin Tang, Cuirong Li, Meng Liao, Weijia Zhou, Yuchen Xu, Yikai Zhang, Yong-Yuan Zhou, Yuanping Front Oncol Oncology PURPOSE: This study aimed to identify preoperative gadoxetic acid-enhanced MRI features and establish a nomogram for predicting early recurrence (≤ 2 years) of hepatocellular carcinoma (HCC) after ablation therapy. METHODS: A total of 160 patients who underwent gadoxetic acid-enhanced MRI and ablation HCC therapy from January 2015 to June 2018, were included retrospectively and divided into a training cohort (n = 112) and a validation cohort (n = 48). Independent clinical risk factors and gadoxetic acid-enhanced MRI features associated with early recurrence were identified by univariate and multivariate logistic regression analysis and used for construction of a nomogram. The performance of the nomogram was evaluated by discrimination, calibration, and clinical utility. RESULTS: Alpha-fetoprotein (AFP) level, tumor number, arterial peritumoral enhancement, satellite nodule and peritumoral hypointensity at hepatobiliary phases in the training cohort were identified as independent risk factors for early recurrence after ablation. A new nomogram that was constructed with these five features showed an area under the curve (AUC) of 0.843 (95%CI 0.771-0.916) and 0.835 (95%CI 0.713-0.956) in the training and validation cohort, respectively. The calibration curve and decision curve analysis (DCA) suggested that the nomogram had good consistency and clinical utility. CONCLUSIONS: A new nomogram that was constructed using four preoperative gadoxetic acid-enhanced MRI features and serum AFP level can predict the risk of early HCC recurrence after ablation therapy with AUC up to 0.843. The strong performance of this nomogram may help hepatologists to categorize patients’ recurrent risk to guide selecting treatment options and improve postoperative management. Frontiers Media S.A. 2021-05-21 /pmc/articles/PMC8176857/ /pubmed/34094938 http://dx.doi.org/10.3389/fonc.2021.649682 Text en Copyright © 2021 Hu, Song, Zhang, Dai, Tang, Li, Liao, Zhou, Xu, Zhang and Zhou https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Hu, Chengguang Song, Yangda Zhang, Jing Dai, Lin Tang, Cuirong Li, Meng Liao, Weijia Zhou, Yuchen Xu, Yikai Zhang, Yong-Yuan Zhou, Yuanping Preoperative Gadoxetic Acid-Enhanced MRI Based Nomogram Improves Prediction of Early HCC Recurrence After Ablation Therapy |
title | Preoperative Gadoxetic Acid-Enhanced MRI Based Nomogram Improves Prediction of Early HCC Recurrence After Ablation Therapy |
title_full | Preoperative Gadoxetic Acid-Enhanced MRI Based Nomogram Improves Prediction of Early HCC Recurrence After Ablation Therapy |
title_fullStr | Preoperative Gadoxetic Acid-Enhanced MRI Based Nomogram Improves Prediction of Early HCC Recurrence After Ablation Therapy |
title_full_unstemmed | Preoperative Gadoxetic Acid-Enhanced MRI Based Nomogram Improves Prediction of Early HCC Recurrence After Ablation Therapy |
title_short | Preoperative Gadoxetic Acid-Enhanced MRI Based Nomogram Improves Prediction of Early HCC Recurrence After Ablation Therapy |
title_sort | preoperative gadoxetic acid-enhanced mri based nomogram improves prediction of early hcc recurrence after ablation therapy |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8176857/ https://www.ncbi.nlm.nih.gov/pubmed/34094938 http://dx.doi.org/10.3389/fonc.2021.649682 |
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