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Human Microglia Extensively Reconstitute in Humanized-BLT Mice With Human Interleukin-34 Transgene and Support HIV-1 Brain Infection

Humanized bone marrow-liver-thymic (hu-BLT) mice develop a functional immune system in periphery, nevertheless, have a limited reconstitution of human myeloid cells, especially microglia, in CNS. Further, whether bone marrow derived hematopoietic stem and progenitor cells (HSPCs) can enter the brain...

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Detalles Bibliográficos
Autores principales:	Zhang, Jianshui, Lohani, Saroj Chandra, Cheng, Yilun, Wang, Tao, Guo, Lili, Kim, Woong-Ki, Gorantla, Santhi, Li, Qingsheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8176960/ https://www.ncbi.nlm.nih.gov/pubmed/34093573 http://dx.doi.org/10.3389/fimmu.2021.672415

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