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End-stage kidney disease and COVID-19 in an urban safety-net hospital in Boston, Massachusetts

INTRODUCTION: End-stage kidney disease (ESKD) patients are at a high risk for Coronavirus Disease 2019 (COVID-19). In this study, we compared characteristics and outcomes of ESKD and non-ESKD patients admitted with COVID-19 to a large safety-net hospital. METHODS: We evaluated 759 adults (45 with ES...

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Autores principales: Kamel, Mohamed Hassan, Mahmoud, Hassan, Zhen, Aileen, Liu, Jing, Bielick, Catherine G., Mostaghim, Anahita, Lin, Nina, Chitalia, Vipul, Ilori, Titilayo, Waikar, Sushrut S., Upadhyay, Ashish
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8177422/
https://www.ncbi.nlm.nih.gov/pubmed/34086775
http://dx.doi.org/10.1371/journal.pone.0252679
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author Kamel, Mohamed Hassan
Mahmoud, Hassan
Zhen, Aileen
Liu, Jing
Bielick, Catherine G.
Mostaghim, Anahita
Lin, Nina
Chitalia, Vipul
Ilori, Titilayo
Waikar, Sushrut S.
Upadhyay, Ashish
author_facet Kamel, Mohamed Hassan
Mahmoud, Hassan
Zhen, Aileen
Liu, Jing
Bielick, Catherine G.
Mostaghim, Anahita
Lin, Nina
Chitalia, Vipul
Ilori, Titilayo
Waikar, Sushrut S.
Upadhyay, Ashish
author_sort Kamel, Mohamed Hassan
collection PubMed
description INTRODUCTION: End-stage kidney disease (ESKD) patients are at a high risk for Coronavirus Disease 2019 (COVID-19). In this study, we compared characteristics and outcomes of ESKD and non-ESKD patients admitted with COVID-19 to a large safety-net hospital. METHODS: We evaluated 759 adults (45 with ESKD) hospitalized with COVID-19 in Spring of 2020. We examined clinical characteristics, laboratory measures and clinical outcomes. Logistic regression analyses were performed to investigate the associations between ESKD status and outcomes. RESULTS: 73% of ESKD and 47% of non-ESKD patients identified as Black (p = 0.002). ESKD patients were older and had higher rates of comorbidities. Admission ferritin was approximately 6-fold higher in ESKD patients. During hospitalization, the rise in white blood cell count, lactate dehydrogenase, ferritin and C-reactive protein, and the decrease in platelet count and serum albumin were all significantly greater in ESKD patients. The in-hospital mortality was higher for ESKD [18% vs. 10%; multivariable adjusted odds ratio 1.5 (95% CI, 0.48–4.70)], but this did not reach statistical significance. CONCLUSIONS: Among hospitalized COVID-19 patients, ESKD patients had more co-morbidities and more robust inflammatory response than non-ESKD patients. The odds ratio point estimate for death was higher in ESKD patients, but the difference did not reach statistical significance.
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spelling pubmed-81774222021-06-07 End-stage kidney disease and COVID-19 in an urban safety-net hospital in Boston, Massachusetts Kamel, Mohamed Hassan Mahmoud, Hassan Zhen, Aileen Liu, Jing Bielick, Catherine G. Mostaghim, Anahita Lin, Nina Chitalia, Vipul Ilori, Titilayo Waikar, Sushrut S. Upadhyay, Ashish PLoS One Research Article INTRODUCTION: End-stage kidney disease (ESKD) patients are at a high risk for Coronavirus Disease 2019 (COVID-19). In this study, we compared characteristics and outcomes of ESKD and non-ESKD patients admitted with COVID-19 to a large safety-net hospital. METHODS: We evaluated 759 adults (45 with ESKD) hospitalized with COVID-19 in Spring of 2020. We examined clinical characteristics, laboratory measures and clinical outcomes. Logistic regression analyses were performed to investigate the associations between ESKD status and outcomes. RESULTS: 73% of ESKD and 47% of non-ESKD patients identified as Black (p = 0.002). ESKD patients were older and had higher rates of comorbidities. Admission ferritin was approximately 6-fold higher in ESKD patients. During hospitalization, the rise in white blood cell count, lactate dehydrogenase, ferritin and C-reactive protein, and the decrease in platelet count and serum albumin were all significantly greater in ESKD patients. The in-hospital mortality was higher for ESKD [18% vs. 10%; multivariable adjusted odds ratio 1.5 (95% CI, 0.48–4.70)], but this did not reach statistical significance. CONCLUSIONS: Among hospitalized COVID-19 patients, ESKD patients had more co-morbidities and more robust inflammatory response than non-ESKD patients. The odds ratio point estimate for death was higher in ESKD patients, but the difference did not reach statistical significance. Public Library of Science 2021-06-04 /pmc/articles/PMC8177422/ /pubmed/34086775 http://dx.doi.org/10.1371/journal.pone.0252679 Text en © 2021 Kamel et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Kamel, Mohamed Hassan
Mahmoud, Hassan
Zhen, Aileen
Liu, Jing
Bielick, Catherine G.
Mostaghim, Anahita
Lin, Nina
Chitalia, Vipul
Ilori, Titilayo
Waikar, Sushrut S.
Upadhyay, Ashish
End-stage kidney disease and COVID-19 in an urban safety-net hospital in Boston, Massachusetts
title End-stage kidney disease and COVID-19 in an urban safety-net hospital in Boston, Massachusetts
title_full End-stage kidney disease and COVID-19 in an urban safety-net hospital in Boston, Massachusetts
title_fullStr End-stage kidney disease and COVID-19 in an urban safety-net hospital in Boston, Massachusetts
title_full_unstemmed End-stage kidney disease and COVID-19 in an urban safety-net hospital in Boston, Massachusetts
title_short End-stage kidney disease and COVID-19 in an urban safety-net hospital in Boston, Massachusetts
title_sort end-stage kidney disease and covid-19 in an urban safety-net hospital in boston, massachusetts
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8177422/
https://www.ncbi.nlm.nih.gov/pubmed/34086775
http://dx.doi.org/10.1371/journal.pone.0252679
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