Inflammation-induced alterations in maternal-fetal Heme Oxygenase (HO) are associated with sustained innate immune cell dysregulation in mouse offspring

Heme oxygenase-1 (HO-1) is an evolutionarily conserved stress response enzyme and important in pregnancy maintenance, fetal and neonatal outcomes, and a variety of pathologic conditions. Here, we investigated the effects of an exposure to systemic inflammation late in gestation [embryonic day (E)15....

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Autores principales: Ozen, Maide, Zhao, Hui, Kalish, Flora, Yang, Yang, Jantzie, Lauren L., Wong, Ronald J., Stevenson, David K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8177474/
https://www.ncbi.nlm.nih.gov/pubmed/34086785
http://dx.doi.org/10.1371/journal.pone.0252642
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author Ozen, Maide
Zhao, Hui
Kalish, Flora
Yang, Yang
Jantzie, Lauren L.
Wong, Ronald J.
Stevenson, David K.
author_facet Ozen, Maide
Zhao, Hui
Kalish, Flora
Yang, Yang
Jantzie, Lauren L.
Wong, Ronald J.
Stevenson, David K.
author_sort Ozen, Maide
collection PubMed
description Heme oxygenase-1 (HO-1) is an evolutionarily conserved stress response enzyme and important in pregnancy maintenance, fetal and neonatal outcomes, and a variety of pathologic conditions. Here, we investigated the effects of an exposure to systemic inflammation late in gestation [embryonic day (E)15.5] on wild-type (Wt) and HO-1 heterozygous (Het, HO-1(+/-)) mothers, fetuses, and offspring. We show that alterations in fetal liver and spleen HO homeostasis during inflammation late in gestation can lead to a sustained dysregulation of innate immune cell populations and intracellular myeloid HO-1 expression in the spleen through young adolescence [postnatal day 25] in mice.
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spelling pubmed-81774742021-06-07 Inflammation-induced alterations in maternal-fetal Heme Oxygenase (HO) are associated with sustained innate immune cell dysregulation in mouse offspring Ozen, Maide Zhao, Hui Kalish, Flora Yang, Yang Jantzie, Lauren L. Wong, Ronald J. Stevenson, David K. PLoS One Research Article Heme oxygenase-1 (HO-1) is an evolutionarily conserved stress response enzyme and important in pregnancy maintenance, fetal and neonatal outcomes, and a variety of pathologic conditions. Here, we investigated the effects of an exposure to systemic inflammation late in gestation [embryonic day (E)15.5] on wild-type (Wt) and HO-1 heterozygous (Het, HO-1(+/-)) mothers, fetuses, and offspring. We show that alterations in fetal liver and spleen HO homeostasis during inflammation late in gestation can lead to a sustained dysregulation of innate immune cell populations and intracellular myeloid HO-1 expression in the spleen through young adolescence [postnatal day 25] in mice. Public Library of Science 2021-06-04 /pmc/articles/PMC8177474/ /pubmed/34086785 http://dx.doi.org/10.1371/journal.pone.0252642 Text en © 2021 Ozen et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Ozen, Maide
Zhao, Hui
Kalish, Flora
Yang, Yang
Jantzie, Lauren L.
Wong, Ronald J.
Stevenson, David K.
Inflammation-induced alterations in maternal-fetal Heme Oxygenase (HO) are associated with sustained innate immune cell dysregulation in mouse offspring
title Inflammation-induced alterations in maternal-fetal Heme Oxygenase (HO) are associated with sustained innate immune cell dysregulation in mouse offspring
title_full Inflammation-induced alterations in maternal-fetal Heme Oxygenase (HO) are associated with sustained innate immune cell dysregulation in mouse offspring
title_fullStr Inflammation-induced alterations in maternal-fetal Heme Oxygenase (HO) are associated with sustained innate immune cell dysregulation in mouse offspring
title_full_unstemmed Inflammation-induced alterations in maternal-fetal Heme Oxygenase (HO) are associated with sustained innate immune cell dysregulation in mouse offspring
title_short Inflammation-induced alterations in maternal-fetal Heme Oxygenase (HO) are associated with sustained innate immune cell dysregulation in mouse offspring
title_sort inflammation-induced alterations in maternal-fetal heme oxygenase (ho) are associated with sustained innate immune cell dysregulation in mouse offspring
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8177474/
https://www.ncbi.nlm.nih.gov/pubmed/34086785
http://dx.doi.org/10.1371/journal.pone.0252642
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