Heparan sulfate proteoglycans in beta cells provide a critical link between endoplasmic reticulum stress, oxidative stress and type 2 diabetes

Heparan sulfate proteoglycans (HSPGs) consist of a core protein with side chains of the glycosaminoglycan heparan sulfate (HS). We have previously identified (i) the HSPGs syndecan-1 (SDC1), and collagen type XVIII (COL18) inside mouse and human islet beta cells, and (ii) a critical role for HS in b...

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Detalles Bibliográficos
Autores principales: Dhounchak, Sarita, Popp, Sarah K., Brown, Debra J., Laybutt, D. Ross, Biden, Trevor J., Bornstein, Stefan R., Parish, Christopher R., Simeonovic, Charmaine J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8177513/
https://www.ncbi.nlm.nih.gov/pubmed/34086738
http://dx.doi.org/10.1371/journal.pone.0252607

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