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RNA-guided gene editing of the murine gammaherpesvirus 68 genome reduces infectious virus production

Epstein-Barr virus (EBV) and Kaposi sarcoma herpesvirus (KSHV) are cancer-causing viruses that establish lifelong infections in humans. Gene editing using the Cas9-guideRNA (gRNA) CRISPR system has been applied to decrease the latent load of EBV in human Burkitt lymphoma cells. Validating the effica...

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Detalles Bibliográficos
Autores principales:	Foreman, Hui-Chen Chang, Kirillov, Varvara, Paniccia, Gabrielle, Catalano, Demetra, Andrunik, Trevor, Gupta, Swati, Krug, Laurie T., Zhang, Yue
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8177658/ https://www.ncbi.nlm.nih.gov/pubmed/34086743 http://dx.doi.org/10.1371/journal.pone.0252313

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