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(68)Ga-PSMA PET/CT: effect of external cooling on salivary gland uptake
OBJECTIVE: To evaluate the effect that external cooling of the salivary glands (ECSG) has on the uptake of gallium-68-labeled prostate-specific membrane antigen ((68)Ga-PSMA), as an indirect assessment of the capacity of ECSG to reduce the local dose in lutetium-177-PSMA-617 radioligand therapy. MAT...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Publicação do Colégio Brasileiro de Radiologia e Diagnóstico por Imagem
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8177682/ https://www.ncbi.nlm.nih.gov/pubmed/34108764 http://dx.doi.org/10.1590/0100-3984.2020.0044 |
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author | Junqueira, Matheus Zanelatto Rocha, Nelisa Helena Sapienza, Marcelo Tatit |
author_facet | Junqueira, Matheus Zanelatto Rocha, Nelisa Helena Sapienza, Marcelo Tatit |
author_sort | Junqueira, Matheus Zanelatto |
collection | PubMed |
description | OBJECTIVE: To evaluate the effect that external cooling of the salivary glands (ECSG) has on the uptake of gallium-68-labeled prostate-specific membrane antigen ((68)Ga-PSMA), as an indirect assessment of the capacity of ECSG to reduce the local dose in lutetium-177-PSMA-617 radioligand therapy. MATERIALS AND METHODS: Ten patients with prostate cancer were submitted to (68)Ga-PSMA positron emission tomography/computed tomography with unilateral ECSG. The ECSG was started at 30 min before the injection of the radiotracer and maintained until the end of image acquisition (1 h after injection). Each salivary gland was assessed by determining the maximum, mean, and peak standardized uptake values (SUVmax, SUVmean, and SUVpeak, respectively). The volume of each gland was determined in a volume of interest delineated by a threshold SUVmax of 10%. Paired Student’s t-tests were used in order to compare the results. RESULTS: In terms of the SUV parameters, there were no statistically significant differences between the cooled and contralateral salivary glands. However, the mean volume was 27% lower in the cooled parotid glands than in the contralateral parotid glands (p = 0.004). CONCLUSION: The use of ECSG does not appear to reduce (68)Ga-PSMA uptake by the salivary glands. In addition, there is yet no evidence that ECSG is effective in preventing salivary gland toxicity. |
format | Online Article Text |
id | pubmed-8177682 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Publicação do Colégio Brasileiro de Radiologia e Diagnóstico por Imagem |
record_format | MEDLINE/PubMed |
spelling | pubmed-81776822021-06-08 (68)Ga-PSMA PET/CT: effect of external cooling on salivary gland uptake Junqueira, Matheus Zanelatto Rocha, Nelisa Helena Sapienza, Marcelo Tatit Radiol Bras Original Article OBJECTIVE: To evaluate the effect that external cooling of the salivary glands (ECSG) has on the uptake of gallium-68-labeled prostate-specific membrane antigen ((68)Ga-PSMA), as an indirect assessment of the capacity of ECSG to reduce the local dose in lutetium-177-PSMA-617 radioligand therapy. MATERIALS AND METHODS: Ten patients with prostate cancer were submitted to (68)Ga-PSMA positron emission tomography/computed tomography with unilateral ECSG. The ECSG was started at 30 min before the injection of the radiotracer and maintained until the end of image acquisition (1 h after injection). Each salivary gland was assessed by determining the maximum, mean, and peak standardized uptake values (SUVmax, SUVmean, and SUVpeak, respectively). The volume of each gland was determined in a volume of interest delineated by a threshold SUVmax of 10%. Paired Student’s t-tests were used in order to compare the results. RESULTS: In terms of the SUV parameters, there were no statistically significant differences between the cooled and contralateral salivary glands. However, the mean volume was 27% lower in the cooled parotid glands than in the contralateral parotid glands (p = 0.004). CONCLUSION: The use of ECSG does not appear to reduce (68)Ga-PSMA uptake by the salivary glands. In addition, there is yet no evidence that ECSG is effective in preventing salivary gland toxicity. Publicação do Colégio Brasileiro de Radiologia e Diagnóstico por Imagem 2021 /pmc/articles/PMC8177682/ /pubmed/34108764 http://dx.doi.org/10.1590/0100-3984.2020.0044 Text en https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Junqueira, Matheus Zanelatto Rocha, Nelisa Helena Sapienza, Marcelo Tatit (68)Ga-PSMA PET/CT: effect of external cooling on salivary gland uptake |
title | (68)Ga-PSMA PET/CT: effect of external cooling on salivary gland uptake |
title_full | (68)Ga-PSMA PET/CT: effect of external cooling on salivary gland uptake |
title_fullStr | (68)Ga-PSMA PET/CT: effect of external cooling on salivary gland uptake |
title_full_unstemmed | (68)Ga-PSMA PET/CT: effect of external cooling on salivary gland uptake |
title_short | (68)Ga-PSMA PET/CT: effect of external cooling on salivary gland uptake |
title_sort | (68)ga-psma pet/ct: effect of external cooling on salivary gland uptake |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8177682/ https://www.ncbi.nlm.nih.gov/pubmed/34108764 http://dx.doi.org/10.1590/0100-3984.2020.0044 |
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