The CHD8/CHD7/Kismet family links blood-brain barrier glia and serotonin to ASD-associated sleep defects

Sleep disturbances in autism and neurodevelopmental disorders are common and adversely affect patient’s quality of life, yet the underlying mechanisms are understudied. We found that individuals with mutations in CHD8, among the highest-confidence autism risk genes, or CHD7 suffer from disturbed sle...

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Detalles Bibliográficos
Autores principales: Coll-Tané, Mireia, Gong, Naihua N., Belfer, Samuel J., van Renssen, Lara V., Kurtz-Nelson, Evangeline C., Szuperak, Milan, Eidhof, Ilse, van Reijmersdal, Boyd, Terwindt, Isabel, Durkin, Jaclyn, Verheij, Michel M. M., Kim, Chang N., Hudac, Caitlin M., Nowakowski, Tomasz J., Bernier, Raphael A., Pillen, Sigrid, Earl, Rachel K., Eichler, Evan E., Kleefstra, Tjitske, Kayser, Matthew S., Schenck, Annette
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8177706/
https://www.ncbi.nlm.nih.gov/pubmed/34088660
http://dx.doi.org/10.1126/sciadv.abe2626

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