The roles and regulation of the KLF5 transcription factor in cancers

Krüppel‐like factor 5 (KLF5) is a member of the KLF family. Recent studies have suggested that KLF5 regulates the expression of a large number of new target genes and participates in diverse cellular functions, such as stemness, proliferation, apoptosis, autophagy, and migration. In response to mult...

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Detalles Bibliográficos
Autores principales: Luo, Yao, Chen, Ceshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Review Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8177779/
https://www.ncbi.nlm.nih.gov/pubmed/33811715
http://dx.doi.org/10.1111/cas.14910
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author Luo, Yao
Chen, Ceshi
author_facet Luo, Yao
Chen, Ceshi
author_sort Luo, Yao
collection PubMed
description Krüppel‐like factor 5 (KLF5) is a member of the KLF family. Recent studies have suggested that KLF5 regulates the expression of a large number of new target genes and participates in diverse cellular functions, such as stemness, proliferation, apoptosis, autophagy, and migration. In response to multiple signaling pathways, various transcriptional modulation and posttranslational modifications affect the expression level and activity of KLF5. Several transgenic mouse models have revealed the physiological and pathological functions of KLF5 in different cancers. Studies of KLF5 will provide prognostic biomarkers, therapeutic targets, and potential drugs for cancers.
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spelling pubmed-81777792021-06-15 The roles and regulation of the KLF5 transcription factor in cancers Luo, Yao Chen, Ceshi Cancer Sci Review Articles Krüppel‐like factor 5 (KLF5) is a member of the KLF family. Recent studies have suggested that KLF5 regulates the expression of a large number of new target genes and participates in diverse cellular functions, such as stemness, proliferation, apoptosis, autophagy, and migration. In response to multiple signaling pathways, various transcriptional modulation and posttranslational modifications affect the expression level and activity of KLF5. Several transgenic mouse models have revealed the physiological and pathological functions of KLF5 in different cancers. Studies of KLF5 will provide prognostic biomarkers, therapeutic targets, and potential drugs for cancers. John Wiley and Sons Inc. 2021-05-03 2021-06 /pmc/articles/PMC8177779/ /pubmed/33811715 http://dx.doi.org/10.1111/cas.14910 Text en © 2021 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Review Articles
Luo, Yao
Chen, Ceshi
The roles and regulation of the KLF5 transcription factor in cancers
title The roles and regulation of the KLF5 transcription factor in cancers
title_full The roles and regulation of the KLF5 transcription factor in cancers
title_fullStr The roles and regulation of the KLF5 transcription factor in cancers
title_full_unstemmed The roles and regulation of the KLF5 transcription factor in cancers
title_short The roles and regulation of the KLF5 transcription factor in cancers
title_sort roles and regulation of the klf5 transcription factor in cancers
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8177779/
https://www.ncbi.nlm.nih.gov/pubmed/33811715
http://dx.doi.org/10.1111/cas.14910
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