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The roles and regulation of the KLF5 transcription factor in cancers
Krüppel‐like factor 5 (KLF5) is a member of the KLF family. Recent studies have suggested that KLF5 regulates the expression of a large number of new target genes and participates in diverse cellular functions, such as stemness, proliferation, apoptosis, autophagy, and migration. In response to mult...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8177779/ https://www.ncbi.nlm.nih.gov/pubmed/33811715 http://dx.doi.org/10.1111/cas.14910 |
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author | Luo, Yao Chen, Ceshi |
author_facet | Luo, Yao Chen, Ceshi |
author_sort | Luo, Yao |
collection | PubMed |
description | Krüppel‐like factor 5 (KLF5) is a member of the KLF family. Recent studies have suggested that KLF5 regulates the expression of a large number of new target genes and participates in diverse cellular functions, such as stemness, proliferation, apoptosis, autophagy, and migration. In response to multiple signaling pathways, various transcriptional modulation and posttranslational modifications affect the expression level and activity of KLF5. Several transgenic mouse models have revealed the physiological and pathological functions of KLF5 in different cancers. Studies of KLF5 will provide prognostic biomarkers, therapeutic targets, and potential drugs for cancers. |
format | Online Article Text |
id | pubmed-8177779 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-81777792021-06-15 The roles and regulation of the KLF5 transcription factor in cancers Luo, Yao Chen, Ceshi Cancer Sci Review Articles Krüppel‐like factor 5 (KLF5) is a member of the KLF family. Recent studies have suggested that KLF5 regulates the expression of a large number of new target genes and participates in diverse cellular functions, such as stemness, proliferation, apoptosis, autophagy, and migration. In response to multiple signaling pathways, various transcriptional modulation and posttranslational modifications affect the expression level and activity of KLF5. Several transgenic mouse models have revealed the physiological and pathological functions of KLF5 in different cancers. Studies of KLF5 will provide prognostic biomarkers, therapeutic targets, and potential drugs for cancers. John Wiley and Sons Inc. 2021-05-03 2021-06 /pmc/articles/PMC8177779/ /pubmed/33811715 http://dx.doi.org/10.1111/cas.14910 Text en © 2021 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Review Articles Luo, Yao Chen, Ceshi The roles and regulation of the KLF5 transcription factor in cancers |
title | The roles and regulation of the KLF5 transcription factor in cancers |
title_full | The roles and regulation of the KLF5 transcription factor in cancers |
title_fullStr | The roles and regulation of the KLF5 transcription factor in cancers |
title_full_unstemmed | The roles and regulation of the KLF5 transcription factor in cancers |
title_short | The roles and regulation of the KLF5 transcription factor in cancers |
title_sort | roles and regulation of the klf5 transcription factor in cancers |
topic | Review Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8177779/ https://www.ncbi.nlm.nih.gov/pubmed/33811715 http://dx.doi.org/10.1111/cas.14910 |
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