Antibody‐drug conjugate MORAb‐202 exhibits long‐lasting antitumor efficacy in TNBC PDx models

The antibody‐drug conjugate (ADC) MORAb‐202, consisting of farletuzumab paired with a cathepsin B–cleavable linker and eribulin, targets folate receptor alpha (FRA), which is frequently overexpressed in various tumor types. MORAb‐202 was highly cytotoxic to FRA‐positive cells in vitro, with limited...

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Detalles Bibliográficos
Autores principales: Furuuchi, Keiji, Rybinski, Katherine, Fulmer, James, Moriyama, Tomoyuki, Drozdowski, Brian, Soto, Allis, Fernando, Shawn, Wilson, Kerrianne, Milinichik, Andrew, Dula, Mary Lou, Tanaka, Keigo, Cheng, Xin, Albone, Earl, Uenaka, Toshimitsu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8177789/
https://www.ncbi.nlm.nih.gov/pubmed/33756060
http://dx.doi.org/10.1111/cas.14898

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