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Spontaneous neural synchrony links intrinsic spinal sensory and motor networks during unconsciousness
Non-random functional connectivity during unconsciousness is a defining feature of supraspinal networks. However, its generalizability to intrinsic spinal networks remains incompletely understood. Previously, Barry et al., 2014 used fMRI to reveal bilateral resting state functional connectivity with...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8177891/ https://www.ncbi.nlm.nih.gov/pubmed/34042587 http://dx.doi.org/10.7554/eLife.66308 |
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author | McPherson, Jacob Graves Bandres, Maria F |
author_facet | McPherson, Jacob Graves Bandres, Maria F |
author_sort | McPherson, Jacob Graves |
collection | PubMed |
description | Non-random functional connectivity during unconsciousness is a defining feature of supraspinal networks. However, its generalizability to intrinsic spinal networks remains incompletely understood. Previously, Barry et al., 2014 used fMRI to reveal bilateral resting state functional connectivity within sensory-dominant and, separately, motor-dominant regions of the spinal cord. Here, we record spike trains from large populations of spinal interneurons in vivo in rats and demonstrate that spontaneous functional connectivity also links sensory- and motor-dominant regions during unconsciousness. The spatiotemporal patterns of connectivity could not be explained by latent afferent activity or by populations of interconnected neurons spiking randomly. We also document connection latencies compatible with mono- and disynaptic interactions and putative excitatory and inhibitory connections. The observed activity is consistent with the hypothesis that salient, experience-dependent patterns of neural transmission introduced during behavior or by injury/disease are reactivated during unconsciousness. Such a spinal replay mechanism could shape circuit-level connectivity and ultimately behavior. |
format | Online Article Text |
id | pubmed-8177891 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-81778912021-06-07 Spontaneous neural synchrony links intrinsic spinal sensory and motor networks during unconsciousness McPherson, Jacob Graves Bandres, Maria F eLife Neuroscience Non-random functional connectivity during unconsciousness is a defining feature of supraspinal networks. However, its generalizability to intrinsic spinal networks remains incompletely understood. Previously, Barry et al., 2014 used fMRI to reveal bilateral resting state functional connectivity within sensory-dominant and, separately, motor-dominant regions of the spinal cord. Here, we record spike trains from large populations of spinal interneurons in vivo in rats and demonstrate that spontaneous functional connectivity also links sensory- and motor-dominant regions during unconsciousness. The spatiotemporal patterns of connectivity could not be explained by latent afferent activity or by populations of interconnected neurons spiking randomly. We also document connection latencies compatible with mono- and disynaptic interactions and putative excitatory and inhibitory connections. The observed activity is consistent with the hypothesis that salient, experience-dependent patterns of neural transmission introduced during behavior or by injury/disease are reactivated during unconsciousness. Such a spinal replay mechanism could shape circuit-level connectivity and ultimately behavior. eLife Sciences Publications, Ltd 2021-05-27 /pmc/articles/PMC8177891/ /pubmed/34042587 http://dx.doi.org/10.7554/eLife.66308 Text en © 2021, McPherson and Bandres https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Neuroscience McPherson, Jacob Graves Bandres, Maria F Spontaneous neural synchrony links intrinsic spinal sensory and motor networks during unconsciousness |
title | Spontaneous neural synchrony links intrinsic spinal sensory and motor networks during unconsciousness |
title_full | Spontaneous neural synchrony links intrinsic spinal sensory and motor networks during unconsciousness |
title_fullStr | Spontaneous neural synchrony links intrinsic spinal sensory and motor networks during unconsciousness |
title_full_unstemmed | Spontaneous neural synchrony links intrinsic spinal sensory and motor networks during unconsciousness |
title_short | Spontaneous neural synchrony links intrinsic spinal sensory and motor networks during unconsciousness |
title_sort | spontaneous neural synchrony links intrinsic spinal sensory and motor networks during unconsciousness |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8177891/ https://www.ncbi.nlm.nih.gov/pubmed/34042587 http://dx.doi.org/10.7554/eLife.66308 |
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