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Curative intent treatment of late presented extragastrointestinal stromal tumor: two identical case reports with literature review

Gastrointestinal stromal tumors (GISTs) occurring outside the gastrointestinal tract are known as extragastrointestinal stromal tumors (EGIST). They share some common histopathologic and molecular characteristics. This report describes two female patients who were suspected of having a mesenteric GI...

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Autores principales: Kadel, Dhruba, Bhuju, Shashinda, Thapa, Bikash Raj, Chalise, Sanat, Kumar Sah, Sandeep
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8177904/
https://www.ncbi.nlm.nih.gov/pubmed/34104404
http://dx.doi.org/10.1093/jscr/rjab220
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author Kadel, Dhruba
Bhuju, Shashinda
Thapa, Bikash Raj
Chalise, Sanat
Kumar Sah, Sandeep
author_facet Kadel, Dhruba
Bhuju, Shashinda
Thapa, Bikash Raj
Chalise, Sanat
Kumar Sah, Sandeep
author_sort Kadel, Dhruba
collection PubMed
description Gastrointestinal stromal tumors (GISTs) occurring outside the gastrointestinal tract are known as extragastrointestinal stromal tumors (EGIST). They share some common histopathologic and molecular characteristics. This report describes two female patients who were suspected of having a mesenteric GIST, but opted for surveillance rather than definitive treatment. Upon reassessment, both patients demonstrated increased tumor mass with no evidence of distant metastasis. The intraoperative findings confirmed the conclusion of clinical and imaging studies performed preoperatively and radical excisions were performed. Histopathological examination (spindle cell neoplasm) and immunohistochemistry (CD117) confirmed EGIST. Both patients underwent Imatinib therapy following surgery with no evidence of disease recurrence or metastasis upon follow up. Although sharing histologic features with GIST, EGIST frequently demonstrates distinct characteristics that facilitate the proper diagnosis and management of EGIST. Since it is a rare and aggressive disease with a poor outcome, early detection and curative surgical resection remains the mainstay of treatment.
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spelling pubmed-81779042021-06-07 Curative intent treatment of late presented extragastrointestinal stromal tumor: two identical case reports with literature review Kadel, Dhruba Bhuju, Shashinda Thapa, Bikash Raj Chalise, Sanat Kumar Sah, Sandeep J Surg Case Rep Case Series Gastrointestinal stromal tumors (GISTs) occurring outside the gastrointestinal tract are known as extragastrointestinal stromal tumors (EGIST). They share some common histopathologic and molecular characteristics. This report describes two female patients who were suspected of having a mesenteric GIST, but opted for surveillance rather than definitive treatment. Upon reassessment, both patients demonstrated increased tumor mass with no evidence of distant metastasis. The intraoperative findings confirmed the conclusion of clinical and imaging studies performed preoperatively and radical excisions were performed. Histopathological examination (spindle cell neoplasm) and immunohistochemistry (CD117) confirmed EGIST. Both patients underwent Imatinib therapy following surgery with no evidence of disease recurrence or metastasis upon follow up. Although sharing histologic features with GIST, EGIST frequently demonstrates distinct characteristics that facilitate the proper diagnosis and management of EGIST. Since it is a rare and aggressive disease with a poor outcome, early detection and curative surgical resection remains the mainstay of treatment. Oxford University Press 2021-06-04 /pmc/articles/PMC8177904/ /pubmed/34104404 http://dx.doi.org/10.1093/jscr/rjab220 Text en Published by Oxford University Press and JSCR Publishing Ltd. © The Author(s) 2021. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Series
Kadel, Dhruba
Bhuju, Shashinda
Thapa, Bikash Raj
Chalise, Sanat
Kumar Sah, Sandeep
Curative intent treatment of late presented extragastrointestinal stromal tumor: two identical case reports with literature review
title Curative intent treatment of late presented extragastrointestinal stromal tumor: two identical case reports with literature review
title_full Curative intent treatment of late presented extragastrointestinal stromal tumor: two identical case reports with literature review
title_fullStr Curative intent treatment of late presented extragastrointestinal stromal tumor: two identical case reports with literature review
title_full_unstemmed Curative intent treatment of late presented extragastrointestinal stromal tumor: two identical case reports with literature review
title_short Curative intent treatment of late presented extragastrointestinal stromal tumor: two identical case reports with literature review
title_sort curative intent treatment of late presented extragastrointestinal stromal tumor: two identical case reports with literature review
topic Case Series
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8177904/
https://www.ncbi.nlm.nih.gov/pubmed/34104404
http://dx.doi.org/10.1093/jscr/rjab220
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