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Clinical review of cerebral venous thrombosis in the context of COVID-19 vaccinations: Evaluation, management, and scientific questions
BACKGROUND: Vaccine induced immune mediated thrombocytopenia or VITT, is a recent and rare phenomenon of thrombosis with thrombocytopenia, frequently including cerebral venous thromboses (CVT), that has been described following vaccination with adenovirus vaccines ChAdOx1 nCOV-19 (AstraZeneca) and A...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Authors. Published by Elsevier B.V.
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8178065/ https://www.ncbi.nlm.nih.gov/pubmed/34134058 http://dx.doi.org/10.1016/j.jns.2021.117532 |
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| author | Thakur, Kiran T. Tamborska, Arina Wood, Greta K. McNeill, Emily Roh, David Akpan, Imo J. Miller, Eliza C. Bautista, Alyssa Claassen, Jan Kim, Carla Y. Guekht, Alla Pardo, Carlos A. Williams, Olajide García-Azorín, David Prasad, Kameshwar Schmutzhard, Erich Michael, Benedict D. Chou, Sherry H.-Y. Winkler, Andrea S. Solomon, Tom Elkind, Mitchell S. |
| author_facet | Thakur, Kiran T. Tamborska, Arina Wood, Greta K. McNeill, Emily Roh, David Akpan, Imo J. Miller, Eliza C. Bautista, Alyssa Claassen, Jan Kim, Carla Y. Guekht, Alla Pardo, Carlos A. Williams, Olajide García-Azorín, David Prasad, Kameshwar Schmutzhard, Erich Michael, Benedict D. Chou, Sherry H.-Y. Winkler, Andrea S. Solomon, Tom Elkind, Mitchell S. |
| author_sort | Thakur, Kiran T. |
| collection | PubMed |
| description | BACKGROUND: Vaccine induced immune mediated thrombocytopenia or VITT, is a recent and rare phenomenon of thrombosis with thrombocytopenia, frequently including cerebral venous thromboses (CVT), that has been described following vaccination with adenovirus vaccines ChAdOx1 nCOV-19 (AstraZeneca) and Ad26.COV2·S Johnson and Johnson (Janssen/J&J). The evaluation and management of suspected cases of CVT post COVID-19 vaccination are critical skills for a broad range of healthcare providers. METHODS: A collaborative comprehensive review of literature was conducted among a global group of expert neurologists and hematologists. FINDINGS: Strategies for rapid evaluation and treatment of the CVT in the context of possible VITT exist, including inflammatory marker measurements, PF4 assays, and non-heparin anticoagulation. |
| format | Online Article Text |
| id | pubmed-8178065 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | The Authors. Published by Elsevier B.V. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-81780652021-06-05 Clinical review of cerebral venous thrombosis in the context of COVID-19 vaccinations: Evaluation, management, and scientific questions Thakur, Kiran T. Tamborska, Arina Wood, Greta K. McNeill, Emily Roh, David Akpan, Imo J. Miller, Eliza C. Bautista, Alyssa Claassen, Jan Kim, Carla Y. Guekht, Alla Pardo, Carlos A. Williams, Olajide García-Azorín, David Prasad, Kameshwar Schmutzhard, Erich Michael, Benedict D. Chou, Sherry H.-Y. Winkler, Andrea S. Solomon, Tom Elkind, Mitchell S. J Neurol Sci Review Article BACKGROUND: Vaccine induced immune mediated thrombocytopenia or VITT, is a recent and rare phenomenon of thrombosis with thrombocytopenia, frequently including cerebral venous thromboses (CVT), that has been described following vaccination with adenovirus vaccines ChAdOx1 nCOV-19 (AstraZeneca) and Ad26.COV2·S Johnson and Johnson (Janssen/J&J). The evaluation and management of suspected cases of CVT post COVID-19 vaccination are critical skills for a broad range of healthcare providers. METHODS: A collaborative comprehensive review of literature was conducted among a global group of expert neurologists and hematologists. FINDINGS: Strategies for rapid evaluation and treatment of the CVT in the context of possible VITT exist, including inflammatory marker measurements, PF4 assays, and non-heparin anticoagulation. The Authors. Published by Elsevier B.V. 2021-08-15 2021-06-05 /pmc/articles/PMC8178065/ /pubmed/34134058 http://dx.doi.org/10.1016/j.jns.2021.117532 Text en © 2021 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
| spellingShingle | Review Article Thakur, Kiran T. Tamborska, Arina Wood, Greta K. McNeill, Emily Roh, David Akpan, Imo J. Miller, Eliza C. Bautista, Alyssa Claassen, Jan Kim, Carla Y. Guekht, Alla Pardo, Carlos A. Williams, Olajide García-Azorín, David Prasad, Kameshwar Schmutzhard, Erich Michael, Benedict D. Chou, Sherry H.-Y. Winkler, Andrea S. Solomon, Tom Elkind, Mitchell S. Clinical review of cerebral venous thrombosis in the context of COVID-19 vaccinations: Evaluation, management, and scientific questions |
| title | Clinical review of cerebral venous thrombosis in the context of COVID-19 vaccinations: Evaluation, management, and scientific questions |
| title_full | Clinical review of cerebral venous thrombosis in the context of COVID-19 vaccinations: Evaluation, management, and scientific questions |
| title_fullStr | Clinical review of cerebral venous thrombosis in the context of COVID-19 vaccinations: Evaluation, management, and scientific questions |
| title_full_unstemmed | Clinical review of cerebral venous thrombosis in the context of COVID-19 vaccinations: Evaluation, management, and scientific questions |
| title_short | Clinical review of cerebral venous thrombosis in the context of COVID-19 vaccinations: Evaluation, management, and scientific questions |
| title_sort | clinical review of cerebral venous thrombosis in the context of covid-19 vaccinations: evaluation, management, and scientific questions |
| topic | Review Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8178065/ https://www.ncbi.nlm.nih.gov/pubmed/34134058 http://dx.doi.org/10.1016/j.jns.2021.117532 |
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