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Modifying splice site usage with ModCon: Maintaining the genetic code while changing the underlying mRNP code

Codon degeneracy of amino acid sequences permits an additional “mRNP code” layer underlying the genetic code that is related to RNA processing. In pre-mRNA splicing, splice site usage is determined by both intrinsic strength and sequence context providing RNA binding sites for splicing regulatory pr...

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Detalles Bibliográficos
Autores principales: Ptok, Johannes, Müller, Lisa, Ostermann, Philipp Niklas, Ritchie, Anastasia, Dilthey, Alexander T., Theiss, Stephan, Schaal, Heiner
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8178101/
https://www.ncbi.nlm.nih.gov/pubmed/34136105
http://dx.doi.org/10.1016/j.csbj.2021.05.033