NR4A1 enhances MKP7 expression to diminish JNK activation induced by ROS or ER-stress in pancreatic β cells for surviving

Under adverse conditions, such as sustained or chronic hyperglycemia or hyperlipidemia, ROS (reactive oxygen species) or/and ER-stress (endoplasmic reticulum stress) will be induced in pancreatic β cells. ROS or ER-stress damages β-cells even leads to apoptosis. Previously we found ROS or ER-stress...

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Detalles Bibliográficos
Autores principales: Pu, Ze-qing, Yu, Tian-fu, Liu, Dong, Jin, Cheng-wen, Sadiq, Esha, Qiao, Xiaofei, Li, Xiaojie, Chen, Yuxuan, Zhang, Jinsong, Tian, Mingzhong, Li, Siying, Zhao, Ru-xing, Wang, Xiang-dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8178316/
https://www.ncbi.nlm.nih.gov/pubmed/34088892
http://dx.doi.org/10.1038/s41420-021-00521-0

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