Epigenetic dysregulation of immune-related pathways in cancer: bioinformatics tools and visualization

Cancer immune evasion is one of the hallmarks of carcinogenesis. Cancer cells employ multiple mechanisms to avoid immune recognition and suppress antitumor immune responses. Recently, accumulating evidence has indicated that immune-related pathways are epigenetically dysregulated in cancer. Most imp...

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Autores principales: Berglund, Anders, Putney, Ryan M., Hamaidi, Imene, Kim, Sungjune
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8178403/
https://www.ncbi.nlm.nih.gov/pubmed/33963293
http://dx.doi.org/10.1038/s12276-021-00612-z
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author Berglund, Anders
Putney, Ryan M.
Hamaidi, Imene
Kim, Sungjune
author_facet Berglund, Anders
Putney, Ryan M.
Hamaidi, Imene
Kim, Sungjune
author_sort Berglund, Anders
collection PubMed
description Cancer immune evasion is one of the hallmarks of carcinogenesis. Cancer cells employ multiple mechanisms to avoid immune recognition and suppress antitumor immune responses. Recently, accumulating evidence has indicated that immune-related pathways are epigenetically dysregulated in cancer. Most importantly, the epigenetic footprint of immune-related pathways is associated with the patient outcome, underscoring the crucial need to understand this process. In this review, we summarize the current evidence for epigenetic regulation of immune-related pathways in cancer and describe bioinformatics tools, informative visualization techniques, and resources to help decipher the cancer epigenome.
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spelling pubmed-81784032021-06-17 Epigenetic dysregulation of immune-related pathways in cancer: bioinformatics tools and visualization Berglund, Anders Putney, Ryan M. Hamaidi, Imene Kim, Sungjune Exp Mol Med Review Article Cancer immune evasion is one of the hallmarks of carcinogenesis. Cancer cells employ multiple mechanisms to avoid immune recognition and suppress antitumor immune responses. Recently, accumulating evidence has indicated that immune-related pathways are epigenetically dysregulated in cancer. Most importantly, the epigenetic footprint of immune-related pathways is associated with the patient outcome, underscoring the crucial need to understand this process. In this review, we summarize the current evidence for epigenetic regulation of immune-related pathways in cancer and describe bioinformatics tools, informative visualization techniques, and resources to help decipher the cancer epigenome. Nature Publishing Group UK 2021-05-07 /pmc/articles/PMC8178403/ /pubmed/33963293 http://dx.doi.org/10.1038/s12276-021-00612-z Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Berglund, Anders
Putney, Ryan M.
Hamaidi, Imene
Kim, Sungjune
Epigenetic dysregulation of immune-related pathways in cancer: bioinformatics tools and visualization
title Epigenetic dysregulation of immune-related pathways in cancer: bioinformatics tools and visualization
title_full Epigenetic dysregulation of immune-related pathways in cancer: bioinformatics tools and visualization
title_fullStr Epigenetic dysregulation of immune-related pathways in cancer: bioinformatics tools and visualization
title_full_unstemmed Epigenetic dysregulation of immune-related pathways in cancer: bioinformatics tools and visualization
title_short Epigenetic dysregulation of immune-related pathways in cancer: bioinformatics tools and visualization
title_sort epigenetic dysregulation of immune-related pathways in cancer: bioinformatics tools and visualization
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8178403/
https://www.ncbi.nlm.nih.gov/pubmed/33963293
http://dx.doi.org/10.1038/s12276-021-00612-z
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