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Role of bacterial infections in extracellular vesicles release and impact on immune response
Extracellular vesicle (EV) biology involves understanding the cellular and molecular mechanisms of cell communication. Studies conducted so far with various bacterial infection models demonstrate the release of various types of EVs that include exosomes and microvesicles. Depending upon the infectio...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Chang Gung University
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8178569/ https://www.ncbi.nlm.nih.gov/pubmed/32888911 http://dx.doi.org/10.1016/j.bj.2020.05.006 |
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author | Spencer, Nicole Yeruva, Laxmi |
author_facet | Spencer, Nicole Yeruva, Laxmi |
author_sort | Spencer, Nicole |
collection | PubMed |
description | Extracellular vesicle (EV) biology involves understanding the cellular and molecular mechanisms of cell communication. Studies conducted so far with various bacterial infection models demonstrate the release of various types of EVs that include exosomes and microvesicles. Depending upon the infection and cell type, EV cargo composition changes and ultimately might impact the host immune response and bacterial growth. The mechanisms behind the EVs release, cargo composition, and impact on the immune system have not been fully investigated. Future research needs to include in vivo models to understand the relevance of EVs in host immune function during bacterial infection, and to determine aspects that are shared or species-specific in the host. This would aid in the development of EVs as therapeutics or as markers of disease. |
format | Online Article Text |
id | pubmed-8178569 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Chang Gung University |
record_format | MEDLINE/PubMed |
spelling | pubmed-81785692021-06-15 Role of bacterial infections in extracellular vesicles release and impact on immune response Spencer, Nicole Yeruva, Laxmi Biomed J Review Article Extracellular vesicle (EV) biology involves understanding the cellular and molecular mechanisms of cell communication. Studies conducted so far with various bacterial infection models demonstrate the release of various types of EVs that include exosomes and microvesicles. Depending upon the infection and cell type, EV cargo composition changes and ultimately might impact the host immune response and bacterial growth. The mechanisms behind the EVs release, cargo composition, and impact on the immune system have not been fully investigated. Future research needs to include in vivo models to understand the relevance of EVs in host immune function during bacterial infection, and to determine aspects that are shared or species-specific in the host. This would aid in the development of EVs as therapeutics or as markers of disease. Chang Gung University 2021-04 2020-05-23 /pmc/articles/PMC8178569/ /pubmed/32888911 http://dx.doi.org/10.1016/j.bj.2020.05.006 Text en © 2020 Chang Gung University. Publishing services by Elsevier B.V. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Article Spencer, Nicole Yeruva, Laxmi Role of bacterial infections in extracellular vesicles release and impact on immune response |
title | Role of bacterial infections in extracellular vesicles release and impact on immune response |
title_full | Role of bacterial infections in extracellular vesicles release and impact on immune response |
title_fullStr | Role of bacterial infections in extracellular vesicles release and impact on immune response |
title_full_unstemmed | Role of bacterial infections in extracellular vesicles release and impact on immune response |
title_short | Role of bacterial infections in extracellular vesicles release and impact on immune response |
title_sort | role of bacterial infections in extracellular vesicles release and impact on immune response |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8178569/ https://www.ncbi.nlm.nih.gov/pubmed/32888911 http://dx.doi.org/10.1016/j.bj.2020.05.006 |
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