Novel Phenolic Compounds as Potential Dual EGFR and COX-2 Inhibitors: Design, Semisynthesis, in vitro Biological Evaluation and in silico Insights

INTRODUCTION: Epidermal growth factor receptor (EGFR) inhibition is an imperative therapeutic approach targeting various types of cancer including colorectal, lung, breast, and pancreatic cancer types. Moreover, cyclooxygenase-2 (COX-2) is frequently overexpressed in different types of cancers and h...

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Detalles Bibliográficos
Autores principales: Abdelgawad, Mohamed A, Musa, Arafa, Almalki, Atiah H, Alzarea, Sami I, Mostafa, Ehab M, Hegazy, Mostafa M, Mostafa-Hedeab, Gomaa, Ghoneim, Mohammed M, Parambi, Della G T, Bakr, Rania B, Al-Muaikel, Nayef S, Alanazi, Abdullah S, Alharbi, Metab, Ahmad, Waqas, Bukhari, Syed N A, Al-Sanea, Mohammad M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8178614/
https://www.ncbi.nlm.nih.gov/pubmed/34103896
http://dx.doi.org/10.2147/DDDT.S310820

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