Robustness and innovation along the endocytic route: Lessons from darkness

What mechanisms ensure the loading of a SNARE into a nascent carrier? In this issue, Bowman et al. (2021. J. Cell Biol. https://doi.org/10.1083/jcb.202005173) describe an unprecedented mechanism where two sorting complexes, AP-3 and BLOC-1, the latter bound to syntaxin 13, work as a fail-safe to rec...

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Detalles Bibliográficos
Autores principales: Singleton, Kaela S., Faundez, Victor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Spotlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8178755/
https://www.ncbi.nlm.nih.gov/pubmed/34081082
http://dx.doi.org/10.1083/jcb.202105030
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author Singleton, Kaela S.
Faundez, Victor
author_facet Singleton, Kaela S.
Faundez, Victor
author_sort Singleton, Kaela S.
collection PubMed
description What mechanisms ensure the loading of a SNARE into a nascent carrier? In this issue, Bowman et al. (2021. J. Cell Biol. https://doi.org/10.1083/jcb.202005173) describe an unprecedented mechanism where two sorting complexes, AP-3 and BLOC-1, the latter bound to syntaxin 13, work as a fail-safe to recognize sorting signals in VAMP7, a membrane protein required for fusion to melanosomes. Their observations define one of the first examples of distributed robustness in membrane traffic mechanisms.
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spelling pubmed-81787552022-01-05 Robustness and innovation along the endocytic route: Lessons from darkness Singleton, Kaela S. Faundez, Victor J Cell Biol Spotlight What mechanisms ensure the loading of a SNARE into a nascent carrier? In this issue, Bowman et al. (2021. J. Cell Biol. https://doi.org/10.1083/jcb.202005173) describe an unprecedented mechanism where two sorting complexes, AP-3 and BLOC-1, the latter bound to syntaxin 13, work as a fail-safe to recognize sorting signals in VAMP7, a membrane protein required for fusion to melanosomes. Their observations define one of the first examples of distributed robustness in membrane traffic mechanisms. Rockefeller University Press 2021-06-03 /pmc/articles/PMC8178755/ /pubmed/34081082 http://dx.doi.org/10.1083/jcb.202105030 Text en © 2021 Singleton and Faundez http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Spotlight
Singleton, Kaela S.
Faundez, Victor
Robustness and innovation along the endocytic route: Lessons from darkness
title Robustness and innovation along the endocytic route: Lessons from darkness
title_full Robustness and innovation along the endocytic route: Lessons from darkness
title_fullStr Robustness and innovation along the endocytic route: Lessons from darkness
title_full_unstemmed Robustness and innovation along the endocytic route: Lessons from darkness
title_short Robustness and innovation along the endocytic route: Lessons from darkness
title_sort robustness and innovation along the endocytic route: lessons from darkness
topic Spotlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8178755/
https://www.ncbi.nlm.nih.gov/pubmed/34081082
http://dx.doi.org/10.1083/jcb.202105030
work_keys_str_mv AT singletonkaelas robustnessandinnovationalongtheendocyticroutelessonsfromdarkness
AT faundezvictor robustnessandinnovationalongtheendocyticroutelessonsfromdarkness

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