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Axonal remodeling of the corticospinal tract during neurological recovery after stroke
Stroke remains the leading cause of long-term disability. Hemiparesis is one of the most common post-stroke motor deficits and is largely attributed to loss or disruption of the motor signals from the affected motor cortex. As the only direct descending motor pathway, the corticospinal tract (CST) i...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8178784/ https://www.ncbi.nlm.nih.gov/pubmed/33229733 http://dx.doi.org/10.4103/1673-5374.297060 |
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author | Liu, Zhongwu Xin, Hongqi Chopp, Michael |
author_facet | Liu, Zhongwu Xin, Hongqi Chopp, Michael |
author_sort | Liu, Zhongwu |
collection | PubMed |
description | Stroke remains the leading cause of long-term disability. Hemiparesis is one of the most common post-stroke motor deficits and is largely attributed to loss or disruption of the motor signals from the affected motor cortex. As the only direct descending motor pathway, the corticospinal tract (CST) is the primary pathway to innervate spinal motor neurons, and thus, forms the neuroanatomical basis to control the peripheral muscles for voluntary movements. Here, we review evidence from both experimental animals and stroke patients, regarding CST axonal damage, functional contribution of CST axonal integrity and remodeling to neurological recovery, and therapeutic approaches aimed to enhance CST axonal remodeling after stroke. The new insights gleaned from preclinical and clinical studies may encourage the development of more rational therapeutics with a strategy targeted to promote axonal rewiring for corticospinal innervation, which will significantly impact the current clinical needs of subacute and chronic stroke treatment. |
format | Online Article Text |
id | pubmed-8178784 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-81787842021-06-22 Axonal remodeling of the corticospinal tract during neurological recovery after stroke Liu, Zhongwu Xin, Hongqi Chopp, Michael Neural Regen Res Review Stroke remains the leading cause of long-term disability. Hemiparesis is one of the most common post-stroke motor deficits and is largely attributed to loss or disruption of the motor signals from the affected motor cortex. As the only direct descending motor pathway, the corticospinal tract (CST) is the primary pathway to innervate spinal motor neurons, and thus, forms the neuroanatomical basis to control the peripheral muscles for voluntary movements. Here, we review evidence from both experimental animals and stroke patients, regarding CST axonal damage, functional contribution of CST axonal integrity and remodeling to neurological recovery, and therapeutic approaches aimed to enhance CST axonal remodeling after stroke. The new insights gleaned from preclinical and clinical studies may encourage the development of more rational therapeutics with a strategy targeted to promote axonal rewiring for corticospinal innervation, which will significantly impact the current clinical needs of subacute and chronic stroke treatment. Wolters Kluwer - Medknow 2020-11-16 /pmc/articles/PMC8178784/ /pubmed/33229733 http://dx.doi.org/10.4103/1673-5374.297060 Text en Copyright: © 2021 Neural Regeneration Research https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Review Liu, Zhongwu Xin, Hongqi Chopp, Michael Axonal remodeling of the corticospinal tract during neurological recovery after stroke |
title | Axonal remodeling of the corticospinal tract during neurological recovery after stroke |
title_full | Axonal remodeling of the corticospinal tract during neurological recovery after stroke |
title_fullStr | Axonal remodeling of the corticospinal tract during neurological recovery after stroke |
title_full_unstemmed | Axonal remodeling of the corticospinal tract during neurological recovery after stroke |
title_short | Axonal remodeling of the corticospinal tract during neurological recovery after stroke |
title_sort | axonal remodeling of the corticospinal tract during neurological recovery after stroke |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8178784/ https://www.ncbi.nlm.nih.gov/pubmed/33229733 http://dx.doi.org/10.4103/1673-5374.297060 |
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