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Different body parts’ fat mass and corrected QT interval on the electrocardiogram: The Fasa PERSIAN Cohort Study
BACKGROUND: Previous studies suggested that obesity and fat mass are associated with QT interval prolongation, but the role of different body parts' fat mass is unclear. The associations between total and regional fat mass (FM) and corrected QT interval (QTc) were investigated for the first tim...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8178852/ https://www.ncbi.nlm.nih.gov/pubmed/34090333 http://dx.doi.org/10.1186/s12872-021-02095-2 |
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author | Yazdanpanah, Mohammad Hosein Bahramali, Ehsan Naghizadeh, Mohammad Mehdi Farjam, Mojtaba Mobasheri, Maryam Dadvand, Shiva |
author_facet | Yazdanpanah, Mohammad Hosein Bahramali, Ehsan Naghizadeh, Mohammad Mehdi Farjam, Mojtaba Mobasheri, Maryam Dadvand, Shiva |
author_sort | Yazdanpanah, Mohammad Hosein |
collection | PubMed |
description | BACKGROUND: Previous studies suggested that obesity and fat mass are associated with QT interval prolongation, but the role of different body parts' fat mass is unclear. The associations between total and regional fat mass (FM) and corrected QT interval (QTc) were investigated for the first time in this study. METHODS: In this sub-analysis of Fasa PERSIAN cohort Study data, 3217 subjects aged 35–70 entered our study. Body fat mass was assessed by bioelectrical impedance analysis and QTc interval calculated by the QT interval measured by Cardiax(®) software from ECGs and Bazett’s formula. Uni- and multi-variable linear and logistic regression was performed in IBM SPSS Statistics v23. RESULTS: In males, the fat mass to fat-free mass (FM/FFM) ratio in the trunk, arms, total body, and legs were significantly higher in the prolonged QTc group (QTc > 450 ms). Trunk (B = 0.148), total (B = 0.137), arms (B = 0.124), legs (B = 0.107) fat mass index (FMI) showed significant positive relationship with continuous QTc (P-value < 0.001). Also, just the fat-free mass index of legs had significant positive associations with QTc interval (P-value < 0.05). Surprisingly, in females, the mean of FM/FFM ratio in trunk and legs in the normal QTc group had higher values than the prolonged QTc group (QTc > 470 ms). Also, none of the body composition variables had a significant correlation with continuous QTc. CONCLUSION: Our study suggested that FMI ratios in the trunk, total body, arms, and legs were positively associated with QTc interval in males, respectively, from a higher to a lower beta-coefficient. Such associations were not seen in females. Our study implies that body fat mass may be an independent risk factor for higher QTc interval and, consequently, more cardiovascular events that should be investigated. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12872-021-02095-2. |
format | Online Article Text |
id | pubmed-8178852 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-81788522021-06-07 Different body parts’ fat mass and corrected QT interval on the electrocardiogram: The Fasa PERSIAN Cohort Study Yazdanpanah, Mohammad Hosein Bahramali, Ehsan Naghizadeh, Mohammad Mehdi Farjam, Mojtaba Mobasheri, Maryam Dadvand, Shiva BMC Cardiovasc Disord Research BACKGROUND: Previous studies suggested that obesity and fat mass are associated with QT interval prolongation, but the role of different body parts' fat mass is unclear. The associations between total and regional fat mass (FM) and corrected QT interval (QTc) were investigated for the first time in this study. METHODS: In this sub-analysis of Fasa PERSIAN cohort Study data, 3217 subjects aged 35–70 entered our study. Body fat mass was assessed by bioelectrical impedance analysis and QTc interval calculated by the QT interval measured by Cardiax(®) software from ECGs and Bazett’s formula. Uni- and multi-variable linear and logistic regression was performed in IBM SPSS Statistics v23. RESULTS: In males, the fat mass to fat-free mass (FM/FFM) ratio in the trunk, arms, total body, and legs were significantly higher in the prolonged QTc group (QTc > 450 ms). Trunk (B = 0.148), total (B = 0.137), arms (B = 0.124), legs (B = 0.107) fat mass index (FMI) showed significant positive relationship with continuous QTc (P-value < 0.001). Also, just the fat-free mass index of legs had significant positive associations with QTc interval (P-value < 0.05). Surprisingly, in females, the mean of FM/FFM ratio in trunk and legs in the normal QTc group had higher values than the prolonged QTc group (QTc > 470 ms). Also, none of the body composition variables had a significant correlation with continuous QTc. CONCLUSION: Our study suggested that FMI ratios in the trunk, total body, arms, and legs were positively associated with QTc interval in males, respectively, from a higher to a lower beta-coefficient. Such associations were not seen in females. Our study implies that body fat mass may be an independent risk factor for higher QTc interval and, consequently, more cardiovascular events that should be investigated. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12872-021-02095-2. BioMed Central 2021-06-05 /pmc/articles/PMC8178852/ /pubmed/34090333 http://dx.doi.org/10.1186/s12872-021-02095-2 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Yazdanpanah, Mohammad Hosein Bahramali, Ehsan Naghizadeh, Mohammad Mehdi Farjam, Mojtaba Mobasheri, Maryam Dadvand, Shiva Different body parts’ fat mass and corrected QT interval on the electrocardiogram: The Fasa PERSIAN Cohort Study |
title | Different body parts’ fat mass and corrected QT interval on the electrocardiogram: The Fasa PERSIAN Cohort Study |
title_full | Different body parts’ fat mass and corrected QT interval on the electrocardiogram: The Fasa PERSIAN Cohort Study |
title_fullStr | Different body parts’ fat mass and corrected QT interval on the electrocardiogram: The Fasa PERSIAN Cohort Study |
title_full_unstemmed | Different body parts’ fat mass and corrected QT interval on the electrocardiogram: The Fasa PERSIAN Cohort Study |
title_short | Different body parts’ fat mass and corrected QT interval on the electrocardiogram: The Fasa PERSIAN Cohort Study |
title_sort | different body parts’ fat mass and corrected qt interval on the electrocardiogram: the fasa persian cohort study |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8178852/ https://www.ncbi.nlm.nih.gov/pubmed/34090333 http://dx.doi.org/10.1186/s12872-021-02095-2 |
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