Regulatory mechanisms of immune checkpoints PD-L1 and CTLA-4 in cancer

The cytotoxic T-lymphocyte–associated antigen 4 (CTLA-4)/B7 and programmed death 1 (PD-1)/ programmed cell death-ligand 1 (PD-L1) are two most representative immune checkpoint pathways, which negatively regulate T cell immune function during different phases of T-cell activation. Inhibitors targetin...

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Detalles Bibliográficos
Autores principales: Zhang, Hao, Dai, Ziyu, Wu, Wantao, Wang, Zeyu, Zhang, Nan, Zhang, Liyang, Zeng, Wen-Jing, Liu, Zhixiong, Cheng, Quan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8178863/
https://www.ncbi.nlm.nih.gov/pubmed/34088360
http://dx.doi.org/10.1186/s13046-021-01987-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8178863/
https://www.ncbi.nlm.nih.gov/pubmed/34088360
http://dx.doi.org/10.1186/s13046-021-01987-7

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