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Single point activation of pyridines enables reductive hydroxymethylation
The single point activation of pyridines, using an electron-deficient benzyl group, facilitates the ruthenium-catalysed dearomative functionalisation of a range of electronically diverse pyridine derivatives. This transformation delivers hydroxymethylated piperidines in good yields, allowing rapid a...
Autores principales: | Marinic, Bruno, Hepburn, Hamish B., Grozavu, Alexandru, Dow, Mark, Donohoe, Timothy J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8178984/ https://www.ncbi.nlm.nih.gov/pubmed/34163807 http://dx.doi.org/10.1039/d0sc05656a |
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