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Single point activation of pyridines enables reductive hydroxymethylation

The single point activation of pyridines, using an electron-deficient benzyl group, facilitates the ruthenium-catalysed dearomative functionalisation of a range of electronically diverse pyridine derivatives. This transformation delivers hydroxymethylated piperidines in good yields, allowing rapid a...

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Detalles Bibliográficos
Autores principales:	Marinic, Bruno, Hepburn, Hamish B., Grozavu, Alexandru, Dow, Mark, Donohoe, Timothy J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2020
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8178984/ https://www.ncbi.nlm.nih.gov/pubmed/34163807 http://dx.doi.org/10.1039/d0sc05656a

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