Cargando…
Biomimetic hydrogen-bonding cascade for chemical activation: telling a nucleophile from a base
Hydrogen bonding-assisted polarization is an effective strategy to promote bond-making and bond-breaking chemical reactions. Taking inspiration from the catalytic triad of serine protease active sites, we have devised a conformationally well-defined benzimidazole platform that can be systematically...
| Autores principales: | , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society of Chemistry
2020
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8178988/ https://www.ncbi.nlm.nih.gov/pubmed/34163789 http://dx.doi.org/10.1039/d0sc05067a |