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Total synthesis and complete configurational assignment of amphirionin-2

Amphirionin-2 is a linear polyketide metabolite that exhibits potent and selective cytotoxic activity against certain human cancer cell lines. We disclose herein the first total synthesis of amphirionin-2 and determination of its absolute configuration. Our synthesis featured an extensive use of cob...

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Detalles Bibliográficos
Autores principales:	Kato, Shota, Mizukami, Daichi, Sugai, Tomoya, Tsuda, Masashi, Fuwa, Haruhiko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2020
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8179035/ https://www.ncbi.nlm.nih.gov/pubmed/34163854 http://dx.doi.org/10.1039/d0sc06021f

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