Visible-light-driven palladium-catalyzed Dowd–Beckwith ring expansion/C–C bond formation cascade

A visible-light-induced palladium-catalyzed Dowd–Beckwith ring expansion/C–C bond formation cascade is described. A range of six to nine-membered β-alkenylated cyclic ketones possessing a quaternary carbon center were accessed under mild conditions. Besides styrenes, the electron-rich alkenes such a...

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Detalles Bibliográficos
Autores principales: Chen, Li, Guo, Li-Na, Liu, Shuai, Liu, Le, Duan, Xin-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8179048/
https://www.ncbi.nlm.nih.gov/pubmed/34163941
http://dx.doi.org/10.1039/d0sc04399k
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author Chen, Li
Guo, Li-Na
Liu, Shuai
Liu, Le
Duan, Xin-Hua
author_facet Chen, Li
Guo, Li-Na
Liu, Shuai
Liu, Le
Duan, Xin-Hua
author_sort Chen, Li
collection PubMed
description A visible-light-induced palladium-catalyzed Dowd–Beckwith ring expansion/C–C bond formation cascade is described. A range of six to nine-membered β-alkenylated cyclic ketones possessing a quaternary carbon center were accessed under mild conditions. Besides styrenes, the electron-rich alkenes such as silyl enol ethers and enamides were also compatible, providing the desired β-alkylated cyclic ketones in moderate to good yields.
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spelling pubmed-81790482021-06-22 Visible-light-driven palladium-catalyzed Dowd–Beckwith ring expansion/C–C bond formation cascade Chen, Li Guo, Li-Na Liu, Shuai Liu, Le Duan, Xin-Hua Chem Sci Chemistry A visible-light-induced palladium-catalyzed Dowd–Beckwith ring expansion/C–C bond formation cascade is described. A range of six to nine-membered β-alkenylated cyclic ketones possessing a quaternary carbon center were accessed under mild conditions. Besides styrenes, the electron-rich alkenes such as silyl enol ethers and enamides were also compatible, providing the desired β-alkylated cyclic ketones in moderate to good yields. The Royal Society of Chemistry 2020-12-09 /pmc/articles/PMC8179048/ /pubmed/34163941 http://dx.doi.org/10.1039/d0sc04399k Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Chen, Li
Guo, Li-Na
Liu, Shuai
Liu, Le
Duan, Xin-Hua
Visible-light-driven palladium-catalyzed Dowd–Beckwith ring expansion/C–C bond formation cascade
title Visible-light-driven palladium-catalyzed Dowd–Beckwith ring expansion/C–C bond formation cascade
title_full Visible-light-driven palladium-catalyzed Dowd–Beckwith ring expansion/C–C bond formation cascade
title_fullStr Visible-light-driven palladium-catalyzed Dowd–Beckwith ring expansion/C–C bond formation cascade
title_full_unstemmed Visible-light-driven palladium-catalyzed Dowd–Beckwith ring expansion/C–C bond formation cascade
title_short Visible-light-driven palladium-catalyzed Dowd–Beckwith ring expansion/C–C bond formation cascade
title_sort visible-light-driven palladium-catalyzed dowd–beckwith ring expansion/c–c bond formation cascade
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8179048/
https://www.ncbi.nlm.nih.gov/pubmed/34163941
http://dx.doi.org/10.1039/d0sc04399k
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AT liule visiblelightdrivenpalladiumcatalyzeddowdbeckwithringexpansionccbondformationcascade
AT duanxinhua visiblelightdrivenpalladiumcatalyzeddowdbeckwithringexpansionccbondformationcascade

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