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Arylation of gem-difluoroalkenes using a Pd/Cu Co-catalytic system that avoids β-fluoride elimination

Pd(II)/Cu(I) co-catalyze an arylation reaction of gem-difluoroalkenes using arylsulfonyl chlorides to deliver α,α-difluorobenzyl products. The reaction proceeds through a β,β-difluoroalkyl–Pd intermediate that typically undergoes unimolecular β-F elimination to deliver monofluorinated alkene product...

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Detalles Bibliográficos
Autores principales: Yuan, Kedong, Feoktistova, Taisiia, Cheong, Paul Ha-Yeon, Altman, Ryan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8179108/
https://www.ncbi.nlm.nih.gov/pubmed/34163899
http://dx.doi.org/10.1039/d0sc05192f