Introducing affinity and selectivity into galectin-targeting nanoparticles with fluorinated glycan ligands

Galectins are potential biomarkers and therapeutic targets. However, galectins display broad affinity towards β-galactosides meaning glycan-based (nano)biosensors lack the required selectivity and affinity. Using a polymer-stabilized nanoparticle biosensing platform, we herein demonstrate that the s...

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Detalles Bibliográficos
Autores principales: Richards, Sarah-Jane, Keenan, Tessa, Vendeville, Jean-Baptiste, Wheatley, David E., Chidwick, Harriet, Budhadev, Darshita, Council, Claire E., Webster, Claire S., Ledru, Helene, Baker, Alexander N., Walker, Marc, Galan, M. Carmen, Linclau, Bruno, Fascione, Martin A., Gibson, Matthew I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8179109/
https://www.ncbi.nlm.nih.gov/pubmed/34163856
http://dx.doi.org/10.1039/d0sc05360k

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8179109/
https://www.ncbi.nlm.nih.gov/pubmed/34163856
http://dx.doi.org/10.1039/d0sc05360k

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