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Violet light suppresses lens-induced myopia via neuropsin (OPN5) in mice
Myopia has become a major public health concern, particularly across much of Asia. It has been shown in multiple studies that outdoor activity has a protective effect on myopia. Recent reports have shown that short-wavelength visible violet light is the component of sunlight that appears to play an...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8179197/ https://www.ncbi.nlm.nih.gov/pubmed/34031241 http://dx.doi.org/10.1073/pnas.2018840118 |
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author | Jiang, Xiaoyan Pardue, Machelle T. Mori, Kiwako Ikeda, Shin-ichi Torii, Hidemasa D’Souza, Shane Lang, Richard A. Kurihara, Toshihide Tsubota, Kazuo |
author_facet | Jiang, Xiaoyan Pardue, Machelle T. Mori, Kiwako Ikeda, Shin-ichi Torii, Hidemasa D’Souza, Shane Lang, Richard A. Kurihara, Toshihide Tsubota, Kazuo |
author_sort | Jiang, Xiaoyan |
collection | PubMed |
description | Myopia has become a major public health concern, particularly across much of Asia. It has been shown in multiple studies that outdoor activity has a protective effect on myopia. Recent reports have shown that short-wavelength visible violet light is the component of sunlight that appears to play an important role in preventing myopia progression in mice, chicks, and humans. The mechanism underlying this effect has not been understood. Here, we show that violet light prevents lens defocus–induced myopia in mice. This violet light effect was dependent on both time of day and retinal expression of the violet light sensitive atypical opsin, neuropsin (OPN5). These findings identify Opn5-expressing retinal ganglion cells as crucial for emmetropization in mice and suggest a strategy for myopia prevention in humans. |
format | Online Article Text |
id | pubmed-8179197 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | National Academy of Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-81791972021-06-16 Violet light suppresses lens-induced myopia via neuropsin (OPN5) in mice Jiang, Xiaoyan Pardue, Machelle T. Mori, Kiwako Ikeda, Shin-ichi Torii, Hidemasa D’Souza, Shane Lang, Richard A. Kurihara, Toshihide Tsubota, Kazuo Proc Natl Acad Sci U S A Biological Sciences Myopia has become a major public health concern, particularly across much of Asia. It has been shown in multiple studies that outdoor activity has a protective effect on myopia. Recent reports have shown that short-wavelength visible violet light is the component of sunlight that appears to play an important role in preventing myopia progression in mice, chicks, and humans. The mechanism underlying this effect has not been understood. Here, we show that violet light prevents lens defocus–induced myopia in mice. This violet light effect was dependent on both time of day and retinal expression of the violet light sensitive atypical opsin, neuropsin (OPN5). These findings identify Opn5-expressing retinal ganglion cells as crucial for emmetropization in mice and suggest a strategy for myopia prevention in humans. National Academy of Sciences 2021-06-01 2021-05-24 /pmc/articles/PMC8179197/ /pubmed/34031241 http://dx.doi.org/10.1073/pnas.2018840118 Text en Copyright © 2021 the Author(s). Published by PNAS. https://creativecommons.org/licenses/by/4.0/This open access article is distributed under Creative Commons Attribution License 4.0 (CC BY) (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Biological Sciences Jiang, Xiaoyan Pardue, Machelle T. Mori, Kiwako Ikeda, Shin-ichi Torii, Hidemasa D’Souza, Shane Lang, Richard A. Kurihara, Toshihide Tsubota, Kazuo Violet light suppresses lens-induced myopia via neuropsin (OPN5) in mice |
title | Violet light suppresses lens-induced myopia via neuropsin (OPN5) in mice |
title_full | Violet light suppresses lens-induced myopia via neuropsin (OPN5) in mice |
title_fullStr | Violet light suppresses lens-induced myopia via neuropsin (OPN5) in mice |
title_full_unstemmed | Violet light suppresses lens-induced myopia via neuropsin (OPN5) in mice |
title_short | Violet light suppresses lens-induced myopia via neuropsin (OPN5) in mice |
title_sort | violet light suppresses lens-induced myopia via neuropsin (opn5) in mice |
topic | Biological Sciences |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8179197/ https://www.ncbi.nlm.nih.gov/pubmed/34031241 http://dx.doi.org/10.1073/pnas.2018840118 |
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