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Identification of the peptide epimerase MslH responsible for d-amino acid introduction at the C-terminus of ribosomal peptides

A lasso peptide MS-271 is a ribosomally synthesized and post-translationally modified peptide (RiPP) consisting of 21 amino acids with a d-tryptophan (Trp) at its C terminus. The presence of d-amino acids is rare in RiPPs and few mechanisms of d-amino acid introduction have been characterized. Here,...

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Detalles Bibliográficos
Autores principales: Feng, Zhi, Ogasawara, Yasushi, Dairi, Tohru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8179263/
https://www.ncbi.nlm.nih.gov/pubmed/34164024
http://dx.doi.org/10.1039/d0sc06308h