Small Molecule SARM1 Inhibitors Recapitulate the SARM1(−/−) Phenotype and Allow Recovery of a Metastable Pool of Axons Fated to Degenerate

Axonal degeneration is responsible for disease progression and accumulation of disability in many neurodegenerative conditions. The axonal degenerative process can generate a metastable pool of damaged axons that remain structurally and functionally viable but fated to degenerate in the absence of e...

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Detalles Bibliográficos
Autores principales: Hughes, Robert O., Bosanac, Todd, Mao, Xianrong, Engber, Thomas M., DiAntonio, Aaron, Milbrandt, Jeffrey, Devraj, Rajesh, Krauss, Raul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8179325/
https://www.ncbi.nlm.nih.gov/pubmed/33406435
http://dx.doi.org/10.1016/j.celrep.2020.108588

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8179325/
https://www.ncbi.nlm.nih.gov/pubmed/33406435
http://dx.doi.org/10.1016/j.celrep.2020.108588

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