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A straightforward methodology to overcome solubility challenges for N-terminal cysteinyl peptide segments used in native chemical ligation

One of the main limitations encountered during the chemical synthesis of proteins through native chemical ligation (NCL) is the limited solubility of some of the peptide segments. The most commonly used solution to overcome this problem is to derivatize the segment with a temporary solubilizing tag....

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Detalles Bibliográficos
Autores principales: Abboud, Skander A., Cisse, El hadji, Doudeau, Michel, Bénédetti, Hélène, Aucagne, Vincent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8179351/
https://www.ncbi.nlm.nih.gov/pubmed/34164087
http://dx.doi.org/10.1039/d0sc06001a

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