Computational strategy for intrinsically disordered protein ligand design leads to the discovery of p53 transactivation domain I binding compounds that activate the p53 pathway

Intrinsically disordered proteins or intrinsically disordered regions (IDPs) have gained much attention in recent years due to their vital roles in biology and prevalence in various human diseases. Although IDPs are perceived as attractive therapeutic targets, rational drug design targeting IDPs rem...

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Detalles Bibliográficos
Autores principales: Ruan, Hao, Yu, Chen, Niu, Xiaogang, Zhang, Weilin, Liu, Hanzhong, Chen, Limin, Xiong, Ruoyao, Sun, Qi, Jin, Changwen, Liu, Ying, Lai, Luhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8179352/
https://www.ncbi.nlm.nih.gov/pubmed/34164069
http://dx.doi.org/10.1039/d0sc04670a

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