C4-arylation and domino C4-arylation/3,2-carbonyl migration of indoles by tuning Pd catalytic modes: Pd(i)–Pd(ii) catalysis vs. Pd(ii) catalysis

Efficient C4-arylation and domino C4-arylation/3,2-carbonyl migration of indoles have been developed. The former route enables C4-arylation in a highly efficient and mild manner and the latter route provides an alternative straightforward protocol for synthesis of C2/C4 disubstituted indoles. The me...

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Autores principales: Cheng, Yaohang, Yu, Shijie, He, Yuhang, An, Guanghui, Li, Guangming, Yang, Zhenyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8179361/
https://www.ncbi.nlm.nih.gov/pubmed/34164090
http://dx.doi.org/10.1039/d0sc05409g
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author Cheng, Yaohang
Yu, Shijie
He, Yuhang
An, Guanghui
Li, Guangming
Yang, Zhenyu
author_facet Cheng, Yaohang
Yu, Shijie
He, Yuhang
An, Guanghui
Li, Guangming
Yang, Zhenyu
author_sort Cheng, Yaohang
collection PubMed
description Efficient C4-arylation and domino C4-arylation/3,2-carbonyl migration of indoles have been developed. The former route enables C4-arylation in a highly efficient and mild manner and the latter route provides an alternative straightforward protocol for synthesis of C2/C4 disubstituted indoles. The mechanism studies imply that the different reaction pathways were tuned by the distinct acid additives, which led to either the Pd(i)–Pd(ii) pathway or Pd(ii) catalysis.
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spelling pubmed-81793612021-06-22 C4-arylation and domino C4-arylation/3,2-carbonyl migration of indoles by tuning Pd catalytic modes: Pd(i)–Pd(ii) catalysis vs. Pd(ii) catalysis Cheng, Yaohang Yu, Shijie He, Yuhang An, Guanghui Li, Guangming Yang, Zhenyu Chem Sci Chemistry Efficient C4-arylation and domino C4-arylation/3,2-carbonyl migration of indoles have been developed. The former route enables C4-arylation in a highly efficient and mild manner and the latter route provides an alternative straightforward protocol for synthesis of C2/C4 disubstituted indoles. The mechanism studies imply that the different reaction pathways were tuned by the distinct acid additives, which led to either the Pd(i)–Pd(ii) pathway or Pd(ii) catalysis. The Royal Society of Chemistry 2021-01-07 /pmc/articles/PMC8179361/ /pubmed/34164090 http://dx.doi.org/10.1039/d0sc05409g Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Cheng, Yaohang
Yu, Shijie
He, Yuhang
An, Guanghui
Li, Guangming
Yang, Zhenyu
C4-arylation and domino C4-arylation/3,2-carbonyl migration of indoles by tuning Pd catalytic modes: Pd(i)–Pd(ii) catalysis vs. Pd(ii) catalysis
title C4-arylation and domino C4-arylation/3,2-carbonyl migration of indoles by tuning Pd catalytic modes: Pd(i)–Pd(ii) catalysis vs. Pd(ii) catalysis
title_full C4-arylation and domino C4-arylation/3,2-carbonyl migration of indoles by tuning Pd catalytic modes: Pd(i)–Pd(ii) catalysis vs. Pd(ii) catalysis
title_fullStr C4-arylation and domino C4-arylation/3,2-carbonyl migration of indoles by tuning Pd catalytic modes: Pd(i)–Pd(ii) catalysis vs. Pd(ii) catalysis
title_full_unstemmed C4-arylation and domino C4-arylation/3,2-carbonyl migration of indoles by tuning Pd catalytic modes: Pd(i)–Pd(ii) catalysis vs. Pd(ii) catalysis
title_short C4-arylation and domino C4-arylation/3,2-carbonyl migration of indoles by tuning Pd catalytic modes: Pd(i)–Pd(ii) catalysis vs. Pd(ii) catalysis
title_sort c4-arylation and domino c4-arylation/3,2-carbonyl migration of indoles by tuning pd catalytic modes: pd(i)–pd(ii) catalysis vs. pd(ii) catalysis
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8179361/
https://www.ncbi.nlm.nih.gov/pubmed/34164090
http://dx.doi.org/10.1039/d0sc05409g
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